ReviewFrontiers in oncology2025
Durvalumab consolidation therapy in patients with stage III small cell lung cancer after concurrent chemoradiation: a China-based cost-effectiveness analysis.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03703297 (A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients With Limited Stage Small Cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients With Limited Stage Small Cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy (ADRIATIC)
Who cites it
1 citing paper in PubMed.
- Durvalumab: A Review in Limited-Stage Small Cell Lung Cancer.Targeted oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Limited-stage small-cell lung cancer (LS-SCLC) has suboptimal long-term survival despite standard chemoradiotherapy. Durvalumab, an anti-PD-L1 antibody, demonstrated survival benefits in the ADRIATIC Phase III trial, but its cost-effectiveness in China remains uncertain. This study evaluates the economic value of durvalumab as consolidation therapy for LS-SCLC post-chemoradiotherapy. Methods: A Markov model was constructed using data from the ADRIATIC trial (NCT03703297), simulating three health states: progression-free survival (PFS), progressive disease (PD), and death state, transition probabilities were derived from trial outcomes. A 10-year horizon, 5.0% discount rate, and willingness-to-pay (WTP) thresholds (1-3×per capita gross domestic product (GDP): $12,569.82-$37,709.46/QALY) were applied. All costs were converted to unified currency using the average exchange rate of 1 USD = 7.11 CNY, based on exchange rates from 1 January 2024, to 31 October 2024. Results: The study results demonstrated that while durvalumab provided clinical benefits by extending quality-adjusted life years (QALYs) by 0.44 compared to placebo (2.24 vs. 1.80), its high cost resulted in poor cost-effectiveness within China's healthcare system. The incremental cost reached $108,609.45, yielding an ICER of $245,591.59 per QALY, exceeding China's standard willingness-to-pay thresholds. Sensitivity analyses revealed drug pricing as the most influential factor, where a 30% price reduction could improve the ICER by 30.3%. The negative incremental net monetary benefit (-$107,394.34) further confirmed the economic challenges. These findings suggest that despite its clinical advantages, durvalumab's current pricing makes it economically unviable for routine use in China's LS-SCLC treatment without substantial cost reductions or alternative reimbursement strategies. Conclusion: Durvalumab improves survival in LS-SCLC but lacks cost-effectiveness under current pricing in China. Drug costs and health utilities are critical determinants. Policy measures, such as price negotiation, risk-sharing agreements, or subgroup targeting, may enhance affordability. Balancing clinical benefits with economic burden is essential for optimizing durvalumab's role in LS-SCLC management.
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