Evidence map›Paper›PMID 41267823›Full record

ArticleBrain, behavior, & immunity - health2025

Associations of lifetime stressors and health behaviors with inflammation in young adults previously placed in youth residential care.

David Bürgin, Kristen Nishimi, Vera Clemens, Maria Meier, Eva Unternaehrer, Laura Gurri, Evelyne Bruttin, Nicolas Rohleder, Paul Klauser, Daniella Dwir and 7 more

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In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

David BürginChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Kristen NishimiDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, United States of America.
Vera ClemensDepartment of Child and Adolescent Psychiatry/Psychotherapy, University Ulm, Ulm, Germany.
Maria MeierChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Eva UnternaehrerChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Laura GurriChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Evelyne BruttinChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Nicolas RohlederDepartment of Psychology, Chair of Health Psychology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Paul KlauserCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Daniella DwirCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Nimmy VargheseNeurobiology Lab for Brain Aging and Mental Health, University Psychiatric Clinics Basel, Basel, 4002, Switzerland.
Anne EckertNeurobiology Lab for Brain Aging and Mental Health, University Psychiatric Clinics Basel, Basel, 4002, Switzerland.
Süheyla SekerDepartment of Social Work, Stockholm University, Stockholm, Sweden.
Delfine d'HuartChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Cyril BoonmannChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Marc SchmidChild and Adolescent Psychiatric Research Department, University Psychiatric Hospitals, University of Basel, Basel, Switzerland.
Aoife O'DonovanDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early life stressors (ELS) and stressful life events (SLEs) increase the risk for various physical health conditions, and health behaviors can modulate stress-associated risks. A key mechanism linking both lifetime stress and health behaviors with physical health outcomes is chronic low-grade inflammation. However, it is unclear how both stressor exposure and more proximal health behaviors are associated with inflammation in highly stress-exposed groups. Objectives: Here, we investigated associations of lifetime stressors and health behaviors with peripheral inflammation in a highly stress exposed sample of young adults previously placed within youth residential care in Switzerland. Method: We examined 126 young adults ( Results: Our sample reported high levels of ELS and SLEs, as well as high levels of risky health behaviors. ELS and SLEs were mostly unassociated with young adult health behaviors, and both ELS and SLEs were not associated with inflammatory markers, adjusting for covariates. Regarding behavior, nicotine dependence was associated with higher pro-inflammatory markers and alcohol abuse marginally with a lower anti-inflammatory marker, while physical activity and better sleep quality were associated with lower pro-inflammatory markers, adjusting for covariates. Conclusions: Among individuals with high levels of lifetime stress, cumulative ELS and SLEs were unassociated with inflammation, whereas risky behaviors were associated with higher, and protective behaviors with lower inflammatory markers. Interventions that reduce risky and promote protective health behaviors may lower inflammation and promote long-term health among individuals who have experienced high lifetime stressors exposure.

Indexed as

AdversityCare leaverCytokinesHealth behaviorsInflammationMaltreatmentOut-of-home careStressorsYouth residential care

Identifiers

PMID41267823
PMCPMC12629739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.