Evidence map›Paper›PMID 41267683›Full record

ArticleNAR molecular medicine2025

Oligonucleotides targeting the 3' splice site downstream of a microexon as an innovative therapy for autism.

Ainhoa Martinez-Pizarro, Sara Picó, Mar Alvárez, Julia Pose-Utrilla, Lise Lolle Holm, Thomas K Doktor, Brage S Andresen, José J Lucas, Lourdes R Desviat

Abstract read
In one paragraph

Article in NAR molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ainhoa Martinez-PizarroCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.
Sara PicóCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0003-3022-8084
Mar AlvárezCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.
Julia Pose-UtrillaCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0002-5009-344X
Lise Lolle HolmUniversity of Southern Denmark, Dept. of Biochemistry and Molecular Biology, Odense, Denmark.ORCID https://orcid.org/0000-0002-7978-771X
Thomas K DoktorUniversity of Southern Denmark, Dept. of Biochemistry and Molecular Biology, Odense, Denmark.ORCID https://orcid.org/0000-0002-5315-8325
Brage S AndresenUniversity of Southern Denmark, Dept. of Biochemistry and Molecular Biology, Odense, Denmark.ORCID https://orcid.org/0000-0001-7488-3035
José J LucasCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0003-1597-3916
Lourdes R DesviatCentro de Biología Molecular Severo Ochoa UAM-CSIC, Universidad Autónoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0003-0492-3323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microexons are enriched in genes linked to autism spectrum disorders (ASDs). We have previously demonstrated decreased inclusion of a neuronal specific 24 bp microexon of the translational regulator

Identifiers

PMID41267683
PMCPMC12628316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.