Evidence map›Paper›PMID 41267661›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2025

Early influenza virus characterisation and vaccine effectiveness in England in autumn 2025, a period dominated by influenza A(H3N2) subclade K.

Freja Cm Kirsebom, Catherine Thompson, Tiina Talts, Beatrix Kele, Heather J Whitaker, Nick Andrews, Nurin Abdul Aziz, Christopher Rawlinson, Rebecca E Green, Catherine Quinot and 11 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

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  9. Loss of hemagglutination ability by H3N2 influenza A virus, subclade K.bioRxiv : the preprint server for biology · 2026
    Article
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  12. Northern Hemisphere 2025/26 influenza vaccine effectiveness during months with influenza A(H3N2) subclade K predominance- Suzhou, Eastern China.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Freja Cm KirsebomImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Catherine ThompsonRespiratory Virus Unit (RVU), UK Health Security Agency, Colindale, London, United Kingdom.
Tiina TaltsRespiratory Virus Unit (RVU), UK Health Security Agency, Colindale, London, United Kingdom.
Beatrix KeleRespiratory Virus Unit (RVU), UK Health Security Agency, Colindale, London, United Kingdom.
Heather J WhitakerModelling Division, UK Health Security Agency, Colindale, London, United Kingdom.
Nick AndrewsImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Nurin Abdul AzizImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Christopher RawlinsonImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Rebecca E GreenImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Catherine QuinotImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Nicholas GardnerImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Elizabeth WallerImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Alex AllenImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Conall H WatsonImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Suzanna Lr McDonaldImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.
Maria ZambonRespiratory Virus Unit (RVU), UK Health Security Agency, Colindale, London, United Kingdom.
Richard PebodyNIHR Health Protection Research Unit in Respiratory Infections, Imperial College London, United Kingdom.
Mary RamsayPublic Health Programmes Directorate, UK Health Security Agency, Colindale, London, United Kingdom.
Katja HoschlerRespiratory Virus Unit (RVU), UK Health Security Agency, Colindale, London, United Kingdom.
Anika SinganayagamRespiratory Virus Unit (RVU), UK Health Security Agency, Colindale, London, United Kingdom.
Jamie Lopez BernalImmunisation and Vaccine-preventable Diseases Division, UK Health Security Agency, Colindale, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A(H3N2) subclade K (J.2.4.1) has dominated the 2025/26 season start in England. Post-infection ferret antisera raised against northern hemisphere 2025/26 vaccine strains showed reduced reactivity to subclade K viruses in England, aligning with World Health Organization reports. Nevertheless, early post-vaccination, vaccine effectiveness against influenza-related emergency department attendances and hospital admissions remained within typical ranges, at 72-75% in children and adolescents (< 18 years) and 32-39% in adults. Hence, vaccination remains effective against clinical disease caused by influenza A(H3N2) viruses.

Indexed as

Influenza A Virus, H3N2 SubtypeInfluenza, HumanInfluenza VaccinesVaccine EfficacyAdolescentAdultAgedAnimalsAntibodies, ViralChildChild, PreschoolEnglandFemaleFerretsHospitalizationHumansAntibodies, ViralInfluenza VaccinesA(H3N2)InfluenzaJ.2.4.1subclade Ktest-negative designvaccine effectiveness

Identifiers

PMID41267661
PMCPMC12639273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.