Evidence map›Paper›PMID 41267551›Full record

ArticleThe Kaohsiung journal of medical sciences2026

USP54 Promotes Ferroptosis in Non-Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription.

Rui-Shi Wei, Yong-Ping Liu, Chun-Dong Gu, Shi-Lei Zhao, Li Feng, Jian-Rong Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rui-Shi WeiDepartment of Thoracic Surgery, Changzhou Cancer Hospital, Changzhou, Jiangsu, China.ORCID https://orcid.org/0000-0001-6733-5209
Yong-Ping LiuDepartment of Oncology, Changzhou Cancer Hospital, Changzhou, Jiangsu, China.
Chun-Dong GuDepartment of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Shi-Lei ZhaoDepartment of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Li FengDepartment of Thoracic Surgery, Changzhou Cancer Hospital, Changzhou, Jiangsu, China.
Jian-Rong YuDepartment of Thoracic Surgery, Changzhou Cancer Hospital, Changzhou, Jiangsu, China.ORCID https://orcid.org/0009-0005-6099-7142

Funding

Applied basic research project of Changzhou Science and Technology Bureau CJ20241026Changzhou Health Commission Science and Technology Youth Project QN202455Health Young Scientific and Technological Talent Development Plan of Changzhou Medical Development Center and Changzhou Medical Association CYF2022007/lcyx2022004Young Talent Development Plan of Changzhou Health Commission CZQM2022019
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5-year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments. We examined the role of USP54 in ferroptosis using an MTT assay and assessed the levels of reactive oxygen species (ROS), ferrous iron (Fe

Indexed as

Carcinoma, Non-Small-Cell LungFerroptosisHepatocyte Nuclear Factor 3-betaLong-Chain-Fatty-Acid-CoA LigaseLung NeoplasmsUbiquitin-Specific ProteasesAmino Acid Transport System y+Cell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMalondialdehydeReactive Oxygen SpeciesTranscription, GeneticUbiquitinationACSL4 protein, humanAmino Acid Transport System y+Hepatocyte Nuclear Factor 3-betaLong-Chain-Fatty-Acid-CoA LigaseMalondialdehydeReactive Oxygen SpeciesSLC7A11 protein, humanUbiquitin-Specific ProteasesACSL4ferroptosisFOXA2non‐small cell lung cancerUSP54

Identifiers

PMID41267551
PMCPMC13248803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.