ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026
Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis.
Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectivesSystemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis of the skin and/or internal organs. Emerging evidence suggests that subcutaneous adipose tissue may contribute to systemic inflammation and fibrosis in SSc. This study aimed to conduct a comprehensive analysis of immune cell composition in SSc by simultaneously examining blood, skin, and subcutaneous adipose tissue. PATIENTS AND
methodsUsing spectral flow cytometry, we profiled major immune cell subsets and explored their associations with clinical features of SSc.
resultsPatients with mild skin fibrosis (low mRSS) exhibited increased cDC1, moDC, and ThGM-CSF cells in the skin, alongside with an influx of Th22 cells and reduced terminal NK cells in subcutaneous adipose tissue. In SSc patients with lung fibrosis, peripheral blood showed decreased NK cells and increased CD8
conclusionsThese findings highlight the potential role of distinct immune subsets for disease progression and tissue-specific fibrosis in SSc.
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