Evidence map›Paper›PMID 41267133›Full record

ArticleGenome biology2025

Structure-enhanced graph meta learning for few-shot gene regulatory network inference.

Weiming Yu, Zhuobin Chen, Yaohua Hu, Jing Qin, Le Ou-Yang

Abstract read
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weiming YuGuangdong Provincial Key Laboratory of Intelligent Information Processing, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Zhuobin ChenSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China.
Yaohua HuSchool of Mathematical Sciences, Shenzhen University, Shenzhen, Guangdong, 518060, China. mayhhu@szu.edu.cn.
Jing QinSchool of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China. qinj29@mail.sysu.edu.cn.
Le Ou-YangSMBU-MSU-BIT Joint Laboratory on Bioinformatics and Engineering Biology, Faculty of Engineering, Shenzhen MSU-BIT University, Shenzhen, Guangdong, 518172, China. leouyang@smbu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2024B1515020059National Natural Science Foundation of China 12222112, 12426311 and 32170655National Natural Science Foundation of China 62173235, 62473266Shenzhen Science and Technology Innovation Program RCJC20221008092753082 and RCYX20231211090222026Shenzhen Science and Technology Innovation Program RCYX20221008092922051, JCYJ20230808105802006
6 · The paper itself

Abstract

Inferring gene regulatory networks (GRNs) is essential for understanding biological regulation. Although numerous deep learning approaches have been developed for GRN inference, most require large amounts of labeled data. We present Meta-TGLink, a structure-enhanced graph meta-learning model for few-shot GRN inference. By formulating GRN inference as a link prediction task, Meta-TGLink captures transferable regulatory patterns while reducing dependence on extensive labeled datasets. The model combines graph neural networks with Transformer architectures to integrate relational and positional information, thereby improving predictive performance under data-scarce conditions. Experiments on real datasets demonstrate its superiority over state-of-the-art baselines, particularly in cross-domain few-shot scenarios.

Indexed as

Computational BiologyGene Regulatory NetworksAlgorithmsDeep LearningHumansNeural Networks, ComputerGene regulatory networksGraph meta learningGraph neural networksNetworks inference

Identifiers

PMID41267133
PMCPMC12636225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.