Evidence map›Paper›PMID 41267068›Full record

ArticleGenome biology2025

X-LDR: an atlas of linkage disequilibrium across species.

Tian-Neng Zhu, Xing Huang, Meng-Yuan Yang, Guo-An Qi, Qi-Xin Zhang, Feng Lin, Wenjing Zhang, Zhe Zhang, Xin Jin, Hou-Feng Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tian-Neng ZhuDepartment of Genetic and Genomic Medicine, Center for Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xing HuangInstitute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang, China.
Meng-Yuan YangDiseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Guo-An QiAdvanced Seed Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, Zhejiang, China.
Qi-Xin ZhangDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Feng LinInstitute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang, China.
Wenjing ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Zhe ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Xin JinBGI Research, Shenzhen, Guangdong, China.
Hou-Feng ZhengCenter for Health and Data Science (CHDS), the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Hai-Ming XuInstitute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang, China.
Shizhou YuMolecular Genetics Key Laboratory of China Tobacco, Guizhou Academy of Tobacco Science, Guiyang, Guizhou, China. yusz@nwafu.edu.cn.
Guo-Bo ChenDepartment of Genetic and Genomic Medicine, Center for Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. chenguobo@gmail.com.

Funding

China National Tobacco Corporation 110202101032 (JY-09)National Natural Science Foundation of China 31771392National Natural Science Foundation of China 32061143019Postdoctoral Fellowship Program of CPSF GZB20250920Zhejiang Traditional Chinese Medicine Administration GZY-ZJ-KJ-23001
6 · The paper itself

Abstract

To reach a genomic scale illustration for linkage disequilibrium (LD), we introduce X-LDR, a stochastic algorithm for biobank-scale data ([Formula: see text], n the sample size, m the number of SNPs, and B iterations). X-LDR can scale the entire genome to high-resolution LD grids, such as nearly 9 million LD grids for UK Biobank ([Formula: see text] and [Formula: see text] million). Various characteristics of LD are discovered in terms of their biological annotation. We also present an unprecedented LD atlas for 25 reference populations that contours the diversity of interspecies LD. The algorithms have been implemented in C++.

Indexed as

AlgorithmsLinkage DisequilibriumAnimalsGenomicsHumansPolymorphism, Single NucleotideGirard-Hutchinson estimationLinkage disequilibriumSoftware

Identifiers

PMID41267068
PMCPMC12636150

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.