Evidence map›Paper›PMID 41266974›Full record

ArticleJournal of neurodevelopmental disorders2025

A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems.

Hannah L Choi, Maia C Lazerwitz, Rachel Powers, Mikaela Rowe, Jamie Wren-Jarvis, Amir Sadikov, Lanya T Cai, Robyn Chu, LaShelle Rullan, Kaitlyn J Trimarchi and 3 more

Abstract read
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In one paragraph

Article in Journal of neurodevelopmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hannah L ChoiDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Maia C LazerwitzDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Rachel PowersDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Mikaela RoweDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Jamie Wren-JarvisDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Amir SadikovDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Lanya T CaiDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
Robyn ChuDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA.
LaShelle RullanCortica Healthcare, San Rafael, 94903, USA.
Kaitlyn J TrimarchiCortica Healthcare, San Rafael, 94903, USA.
Rafael D GarciaCortica Healthcare, San Rafael, 94903, USA.
Elysa J MarcoCortica Healthcare, San Rafael, 94903, USA. drmarco@linccenter.com.
Pratik MukherjeeDepartment of Radiology & Biomedical Imaging, University of California, UCSF, San Francisco, 94143, USA. pratik.mukherjee@ucsf.edu.

Funding

Neural Mechanisms of Sensory OverResponsivityR01MH116950 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCO, ELYSA JILL, MUKHERJEE, PRATIK · 2019 to 2023
$2.7M
NIH HHS 5R01MH116950-04NIMH NIH HHS R01 MH116950
6 · The paper itself

Abstract

backgroundExogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition.

methodsNeurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as “resilient” or “dysregulated” through latent profile analysis.

resultsIn general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern.

conclusionAchieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience.

Indexed as

BrainConnectomeNerve NetPerceptual DisordersChildFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysEmotional regulationFunctional MRI connectivityMultimodal neuroimagingNeurodevelopmentResilienceSensory over-responsivitySensory processing disorder

Identifiers

PMID41266974
PMCPMC12636187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.