Evidence map›Paper›PMID 41266914›Full record

ArticleNMR in biomedicine2026

Reproducibility of Metabolic Mapping Using 2D Multi-Slice Short-TE and GABA-Edited Spin-Echo MRSI at 3T in a Single Protocol.

Helge J Zöllner, Dillip K Senapati, İpek Özdemir, Kimberly L Chan, Georg Oeltzschner, Doris D M Lin, Peter B Barker

Abstract read
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-7148-292X
Dillip K SenapatiRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
İpek ÖzdemirRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kimberly L ChanAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-3091-2073
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Doris D M LinRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Peter B BarkerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-6410-7793

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu · 2021 to 2026
$9.9M
Multi-voxel spectral editing at 3TR01EB028259 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BARKER, PETER B · 2020 to 2024
$1.6M
Simultaneous Downfield and Upfield proton MRSI at 3TR01NS134694 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER B BARKER · 2024 to 2026
$1.4M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
Downfield MR spectroscopic imaging of the human brainK99EB034768 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ÖZDEMIR, İPEK · 2023 to 2024
$273k
Brain metabolism across the lifespan using multi-parametric MRSK99AG080084 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZOELLNER, HELGE JOERN · 2023 to 2024
$212k
NIA NIH HHS K99 AG080084NIA NIH HHS R00 AG062230NIBIB NIH HHS K99 EB034768NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB028259NIBIB NIH HHS R21 EB033516NIH HHS K99 AG080084NIH HHS K99 EB034768NIH HHS P41 EB031771NIH HHS R00 AG062230NIH HHS R01 EB028259NIH HHS R01 NS134694NIH HHS R21 EB033516NINDS NIH HHS R01 NS134694US Department of Defense W81XWH2010819
6 · The paper itself

Abstract

MRSI is a non-invasive tool for mapping metabolic distributions in multi-focal or other diseases where the location of abnormalities may be uncertain. High-concentration metabolites can be investigated at 3T using non-edited MRSI, whereas lower-concentration metabolites, such as GABA, typically require specialized editing techniques because of spectral overlap. This study reports on the reproducibility of a protocol containing both co-localized short-TE and GABA-edited multi-slice spin-echo 2D MRSI. Multi-slice, short-TE (TE 20 ms) and GABA-edited (TE 68 ms) MRSI at a nominal spatial resolution of 2.2 cm

Indexed as

gamma-Aminobutyric AcidMagnetic Resonance ImagingAdolescentAdultBrainChildFemaleHumansMagnetic Resonance SpectroscopyMaleReproducibility of ResultsSpin LabelsYoung Adultgamma-Aminobutyric AcidSpin Labels2D spin‐echoedited MRSIGABA+linear‐combination modelingMRSIreproducibility

Identifiers

PMID41266914
PMCPMC12634484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.