Evidence map›Paper›PMID 41266900›Full record

ArticleBasic research in cardiology2026

Impairment of local metabolic coronary control involves perfusion-contraction matching not supply-demand imbalance.

Salman I Essajee, Gregory M Dick, Selina M Tucker, Cooper M Warne, C Alberto Figueroa, Daniel A Beard, Dirk J Duncker, Johnathan D Tune

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salman I EssajeeDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA.ORCID 0009-0009-0563-3636
Gregory M DickDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA.ORCID 0000-0003-1444-6436
Selina M TuckerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA.ORCID 0000-0002-7959-8716
Cooper M WarneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA.ORCID 0009-0000-3574-4219
C Alberto FigueroaSection of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3934-6506
Daniel A BeardDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0974-2353
Dirk J DunckerDivision of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical School Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0003-2836-2241
Johnathan D TuneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA. johnathan.tune@unthealth.edu.ORCID 0000-0003-2959-0801

Funding

Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale ModelingR01HL158723 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A, FIGUEROA, CARLOS ALBERTO · 2022 to 2025
$2.7M
NHLBI NIH HHS R01 HL158723
6 · The paper itself

Abstract

Understanding of local metabolic control of coronary flow remains stifled by debate around data interpretation and anticipated outcomes. To address this question we performed experiments in a cannulated coronary preparation in swine to precisely control flow as myocardial oxygen consumption (MVO

Indexed as

Coronary CirculationCoronary VesselsMyocardial ContractionMyocardiumOxygen Consumption4-AminopyridineAnimalsDobutamineMalePotassium Channel BlockersSwine4-AminopyridineDobutaminePotassium Channel BlockersCoronary blood flowLocal metabolic controlPerfusion-contraction matchingSupply–demand balance

Identifiers

PMID41266900
PMCPMC12804302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.