Evidence map›Paper›PMID 41266875›Full record

ArticleMolecular psychiatry2026

Shared and divergent alteration of whole-brain connectivity and sensory deficits in multiple autism mouse models.

Tsan-Ting Hsu, Chih-Ping Chen, Ming-Hui Lin, Tzu-En Hung, Tzyy-Nan Haung, Chien-Yao Wang, Yi-Ping Hsueh

Abstract read
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tsan-Ting HsuInstitute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan, ROC.ORCID http://orcid.org/0009-0007-2361-5795
Chih-Ping Chen *Institute of Information Science, Academia Sinica, Taipei, Taiwan, ROC.ORCID http://orcid.org/0009-0004-0058-6053
Ming-Hui Lin *Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan, ROC.ORCID http://orcid.org/0000-0003-0120-7110
Tzu-En Hung *Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan, ROC.ORCID http://orcid.org/0009-0009-0373-4871
Tzyy-Nan Haung *Institute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan, ROC.ORCID http://orcid.org/0000-0002-7509-6305
Chien-Yao WangInstitute of Information Science, Academia Sinica, Taipei, Taiwan, ROC. kinyiu@iis.sinica.edu.tw.ORCID http://orcid.org/0000-0002-2946-8972
Yi-Ping HsuehInstitute of Molecular Biology, Academia Sinica, Taipei, 11529, Taiwan, ROC. yph@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0002-0866-6275

Funding

Academia Sinica AS-IA-111-L01Academia Sinica AS-TP-110-L10Academia Sinica AS-TP-114-M01
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a heterogeneous developmental disconnection syndrome. Identifying circuit deficits is crucial for understanding ASD etiology, yet the involvement of multiple brain regions and genetic variations complicates this analysis. Here, using an AI-powered mapping platform, BM-auto (Brain Mapping with Auto-ROI correction), to analyze a Thy1-YFP reporter, we show that different ASD-associated mutations cause distinct circuit abnormalities but share common deficits in the piriform cortex, a region regulating olfactory discrimination and social behavior patterns. We analyzed the whole-brain distribution of the Thy1-YFP reporter in three ASD mouse models (Tbr1

Indexed as

Autism Spectrum DisorderAutistic DisorderAnimalsBrainBrain MappingDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicMutationNeural PathwaysNeuronsPiriform CortexSocial Behavior

Identifiers

PMID41266875
PMCPMC12999500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.