ArticleFolia microbiologica2025
Antimicrobial photodynamic therapy against multidrug-resistant Staphylococcus aureus using aluminum chloride phthalocyanine nanoemulsion: in vitro and in vivo studies.
Article in Folia microbiologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antimicrobial photodynamic therapy is a promising approach for treating superficial infections caused by resistant strains. This study evaluated the effectiveness of antimicrobial photodynamic therapy against multidrug-resistant Staphylococcus aureus using aluminum chloride phthalocyanine encapsulated in nanoemulsion (NE/ClAlPc) in a rat burn wound model under in vitro and in vivo conditions. In vitro, NE/ClAlPc-mediated antimicrobial photodynamic therapy was assessed for bacterial logarithmic reduction, inhibition of biofilm metabolism, and cytotoxicity on mouse skin fibroblasts (L929) using the MTT assay at 6, 12, and 24 h. Cell migration was evaluated via the scratch wound assay. In vivo, seven groups of male rats with burn wounds were treated with antimicrobial photodynamic therapy. Wound areas were measured, and skin biopsies were analyzed for histological changes and mRNA expression levels of FGF1, TGF-β1, and GPX1 genes using real-time PCR. Results showed an 8-log
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