Evidence map›Paper›PMID 41266864›Full record

ArticleMolecular neurobiology2025

Mendelian Randomization Unlocks Stroke Therapeutics: Dioscin Inhibits CD27-Driven Neuroinflammation via Gut Microbiota Modulation.

Haozhou Tan, Shengli Li, Han Yan, Fangfang Li, Yang Yao, Ying Li, Qian Feng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haozhou TanClinical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.ORCID http://orcid.org/0009-0007-5175-9833
Shengli LiClinical Research Institute, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Han YanCollege of Life Science, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Fangfang LiCollege of Life Science, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Yang YaoCollege of Life Science, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Ying LiClinical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. 154357456@qq.com.ORCID http://orcid.org/0009-0002-2891-9863
Qian FengClinical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. q.feng@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-4752-0770

Funding

the Construction Project of High Level Hospital of Jiangsu Province LCZX202412the hospital-level research project of the affiliated Hospital of Xuzhou Medical University 2022ZL20the medical science and technology innovation project of Xuzhou Municipal Health Commission XWKYHT20230067the Project Funded by Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) XZSYSKF2022020the Xuzhou Science and Technology Program KC22243
6 · The paper itself

Abstract

Research on the gut-brain-immune axis shows it plays a critical role in ischemic stroke, but the exact causal links between gut bacteria imbalance, immune system problems, and brain blood vessel damage remain unclear. To investigate this, we combined multiple types of biological data using a statistical method called Bayesian weighted Mendelian randomization (BWMR). We analyzed large genetic datasets covering 731 immune cell traits, 91 inflammatory proteins, 412 gut microbes and their pathways, and ischemic stroke cases. Shared genetic variants were confirmed using colocalization, and we used computer simulations to explore potential treatments. The analysis found that genetically predicted higher levels of the protein CD27 on specific memory B cells (CD24

Indexed as

Gastrointestinal MicrobiomeMendelian Randomization AnalysisNeuroinflammatory DiseasesStrokeTumor Necrosis Factor Receptor Superfamily, Member 7HumansTumor Necrosis Factor Receptor Superfamily, Member 7Gut microbiotaGWASImmune cellsInflammatory proteinsIschemic strokeMendelian randomization

Identifiers

PMID41266864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.