Evidence map›Paper›PMID 41266858›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Association of surgery delay duration with suicidal ideation in cancer patients: a 3-year prospective cohort study.

Nianqi Liu, Li Deng, Jun Lu, Weidong Wang, Pengfei Zhu, Guangmin Jian, Yongluo Jiang, Yifei Ma, Weizhi Liu, Xinjia Wang and 2 more

Abstract readMulticenter Study
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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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12 authors.

Nianqi Liu *Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, # 1037 Luoyu Road, Wuhan, 430074, China.
Li Deng *Department of Anesthesiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.
Jun Lu *Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Weidong WangDepartment of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Pengfei ZhuDepartment of Clinical, Laboratory & Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guangmin JianDepartment of Clinical, Laboratory & Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yongluo JiangDepartment of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center (SYSUCC), Guangzhou, Guangdong, China.
Yifei MaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Weizhi LiuLab for Post-Traumatic Stress Disorder, Faculty of Psychology and Mental Health, Naval Medical University, # 800 Xiangyin Road, Shanghai, 200433, China.
Xinjia WangDepartment of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Zhilei ShangLab for Post-Traumatic Stress Disorder, Faculty of Psychology and Mental Health, Naval Medical University, # 800 Xiangyin Road, Shanghai, 200433, China. szl035@163.com.
Jianwen ChenFaculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, # 1037 Luoyu Road, Wuhan, 430074, China. chenjianwen@hust.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation Key Project 2023B1515230004Shantou Medical Health Science and Technology Plan 2022.NO.131the Project of Traditional Chinese Medicine Bureau of Guangdong Province 20232084the Science and Technology Special Fund of Guangdong Province of China STKJ2023002
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic caused substantial delays in cancer surgeries. This study investigated the impact of surgery delay duration on the risk of suicidal ideation (SI) in cancer patients.

methodsIn this prospective cohort study, we enrolled cancer patients from three medical centers in China (January-August 2020) whose surgeries were delayed by > 1 month. Patients were followed at 3, 6, 9, 12, 18, 24, and 36 months. SI was assessed at each visit using the Beck Scale for Suicidal Ideation (BSSI). Primary outcomes were the 3-year cumulative incidence of SI, time to SI onset, and SI severity. Intention-to-treat (ITT) and per-protocol analyses were employed for incidence and persistence outcomes, respectively. Findings Among 1864 patients in the ITT analysis, the 3-year cumulative SI incidence was 37.24%. Longer surgery delay was independently associated with a higher risk and earlier onset of SI. Compared to a 1-month delay, the adjusted hazard ratios were 1.89 (95% CI, 1.51-2.37) for a 2-month delay and 3.61 (95% CI, 2.97-4.38) for a 3-month delay. A history of psychiatric disorders or suicide attempts also significantly increased SI risk. Analyses of the per-protocol cohort (n = 1110) further showed that patients with earlier SI onset had more severe symptoms and higher rates of SI persistence (all P < 0.001). Sensitivity analyses confirmed the robustness of these findings.

conclusionsThe duration of surgery delay is a strong, independent predictor of subsequent suicidal ideation in cancer patients. These findings underscore the critical need to integrate mental health screening and early intervention into the surgical care pathway for cancer patients, particularly when treatment delays occur.

Indexed as

COVID-19NeoplasmsSuicidal IdeationTime-to-TreatmentAdultAgedChinaFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsTime FactorsCancer patientsCOVID-19 lockdownProspective cohort studySuicidal ideationSurgery delay

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.