Evidence map›Paper›PMID 41266845›Full record

ArticleJournal of gastroenterology2026

Predictors of lymph node metastases, recurrence, and survival in patients with pedunculated-type T1 colorectal cancer.

Kengo Kasuga, Toshio Uraoka, Yoshiki Kajiwara, Shiro Oka, Shinji Tanaka, Takahiro Nakamura, Shoichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi and 30 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Kengo KasugaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8514, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8514, Japan. toshi_urao@yahoo.co.jp.ORCID http://orcid.org/0000-0002-4425-4331
Yoshiki KajiwaraDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Shinji TanakaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Takahiro NakamuraLaboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan.
Shoichi SaitoDepartment of Lower Gastrointestinal Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Yosuke FukunagaDepartment of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Manabu TakamatsuDepartment of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Hiroshi KawachiDepartment of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Kinichi HottaDivision of Endoscopy, Shizuoka Cancer Center, Sunto, Japan.
Hiroaki IkematsuDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.
Motohiro KojimaDivision of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Yutaka SaitoEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Shigeki SekinePathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
Shinji NagataDepartment of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Kazutaka YamadaColoproctology Center, Takano Hospital, Kumamoto, Japan.
Jun KonishiDepartment of Gastroenterology, Tochigi Cancer Center, Utsunomiya, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Yusuke SaitohDigestive Disease Center, Asahikawa City Hospital, Asahikawa, Japan.
Kenji MatsudaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Kazutomo TogashiDepartment of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Megumi IshiguroHealth Science Research and Development Center, Institute of Science Tokyo Hospital, Tokyo, Japan.
Toshio KuwaiDepartment of Gastroenterology, National Hospital Organization Kure Medical Center, Chugoku Cancer Center, Kure, Japan.
Takashi OkuyamaDepartment of Surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
Akihiro OhuchiDepartment of Gastroenterology, School of Medicine, Kurume University, Kurume, Japan.
Shinobu OhnumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kazuhiro SakamotoDepartment of Coloproctological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Tamotsu SugaiDepartment of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Shiwa, Japan.
Kenji KatsumataDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
Hiro-O MatsushitaDigestive Disease Center, Akita Red Cross Hospital, Akita, Japan.
Hiro-O YamanoDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Keisuke NakaiDepartment of Gastroenterology, Hyogo Medical University, Nishinomiya, Japan.
Naohiko AkimotoDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Hirotoshi KobayashiDepartment of Surgery, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.
Kenichi SugiharaInstitute of Science Tokyo, Tokyo, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe oncologic outcomes of pedunculated-type T1 colorectal cancer (CRC) remain unknown. We determined the risk factors for lymph node metastasis (LNM) and recurrence and evaluated the survival according to the treatment method.

methodsIn this multicenter retrospective study involving 4673 patients with T1 CRC, we analyzed 444 patients with pedunculated-type T1 CRC treated between 2009 and 2016. Treatment included local resection (LR) alone (n = 169), surgery with lymph node (LN) dissection alone (n = 83), and LR followed by additional surgery with LN dissection (n = 192). Factors associated with LNM and recurrence, relapse-free survival (RFS) and overall survival (OS) by treatment were analyzed. The median follow-up period was 64 months.

resultsLNM and recurrence were observed in 25 (5.6%) and 13 (2.9%) cases, respectively. Submucosal invasion depth ≥ 1000 μm (p = 0.0036), positive lymphovascular invasion (p = 0.0007), and budding grade 2/3 (p = 0.0171) were risk factors for LNM. The risk factor for recurrence was tumor size ≥ 20 mm (HR 5.488; 95% CI 1.199-25.12; p = 0.028) in a multivariate analysis. The 5-year RFS rates were 92.5% for LR alone, 94.3% for LR+ surgery, and 90.5% for surgery alone; the 5-year OS rates were 93.1%, 97.1%, and 94.0%, respectively, with no significant difference.

conclusionEven in the specific subset of pedunculated-type T1 CRC, submucosal invasion depth ≥ 1000 μm and budding grade 2/3 are risk factors for LNM. Tumors ≥ 20 mm require careful surveillance for recurrence risk. High RFS and OS rates in LR-alone and LR+ surgery groups suggest LR is appropriate for pedunculated lesions.

Indexed as

Colorectal NeoplasmsNeoplasm Recurrence, LocalAdultAgedAged, 80 and overDisease-Free SurvivalFemaleFollow-Up StudiesHumansLymphatic MetastasisLymph Node ExcisionMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingRetrospective StudiesLymph node metastasisOutcomesPedunculated lesion

Identifiers

PMID41266845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.