Evidence map›Paper›PMID 41266844›Full record

ArticleCommunications engineering2025

Pillar arrays as tunable interfacial barriers for microphysiological systems.

Ishan Goswami, Yongdeok Kim, Gabriel Neiman, Brian Siemons, Jazmin I Velazquez, Kerem Yazgan, Tammy Ng, Sudipta Ashe, Kevin E Healy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Editors' Choice 2025.Communications engineering · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ishan GoswamiDepartment of Bioengineering, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-7097-7656
Yongdeok KimDepartment of Bioengineering, University of California, Berkeley, CA, USA.
Gabriel NeimanDepartment of Bioengineering, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1003-1559
Brian SiemonsDepartment of Bioengineering, University of California, Berkeley, CA, USA.
Jazmin I VelazquezDepartment of Bioengineering, University of California, Berkeley, CA, USA.
Kerem YazganDepartment of Bioengineering, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-7036-182X
Tammy NgDepartment of Materials Science and Engineering, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1338-0025
Sudipta AsheDiabetes Center, University of California, San Francisco, CA, USA.
Kevin E HealyDepartment of Bioengineering, University of California, Berkeley, CA, USA. kehealy@berkeley.edu.

Funding

Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes MellitusUH3DK120004 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALY, KEVIN EDWARD, HEBROK, MATTHIAS · 2020 to 2022
$6.9M
NIDDK NIH HHS UH3 DK120004U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) UH3DK120004
6 · The paper itself

Abstract

We report on the design and fabrication of a circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to inconsistent pore size, complex fabrication and device assembly, and a lack of tunability using a scalable design. Our pillar array overcomes these limitations by providing precise control over pore size, porosity, and hydraulic resistance through simple modifications of pillar dimensions. Serving as an interface between microfluidic compartments, it facilitates cell aggregation for tissue formation and acts as a tunable diffusion barrier that mimics diffusion in vivo. We demonstrate the utility of barrier design to engineer physiologically relevant cardiac microtissues and a heterotypic model with vasculature within the device. The tunable properties offer significant potential for drug screening/testing and disease modeling, enabling comparisons of drug permeability and cell migration in MPS tissue with or without vasculature.

Identifiers

PMID41266844
PMCPMC12634667

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.