ArticleNature metabolism2025
Hepatocyte mitochondrial NAD
Abstract read
In one paragraph
Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- dCas9-metabolic enzyme fusions modulate global and locus-specific gene expression.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Sarmistha MukherjeeDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3258-0287
Ricardo A Velázquez AponteDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7473-3467
Caroline E PerryDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Won Dong LeeLudwig Institute for Cancer Research, Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-2344-171X
Kevin A JanssenDepartment of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6980-9575
Marc NiereDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Gabriel K AdzikaDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4827-7266
Mu-Jie LuDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Hsin-Ru ChanDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Xiangyu ZouDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0004-8551-359X
Beishan ChenDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nicole ByeDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Teresa XiaoDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jin-Seon YookDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.
Oniel SalikAging and Cardiovascular Discovery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
David W FrederickDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ryan B GasparDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7922-3893
Khanh V DoanDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James G DavisDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Joshua D RabinowitzLudwig Institute for Cancer Research, Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1247-4727
Douglas C WallaceDepartment of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nathaniel W SnyderAging and Cardiovascular Discovery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5643-8747
Shingo KajimuraDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0672-5910
Xiaolu A CambronneDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-3547-448X
Mathias ZieglerDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-6961-2396
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-8262-6549
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3MTargeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MUnderstanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failureR01HL165792 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2022 to 2025
$2.7MA liver-specific mitochondrial carrier that controls energy homeostasisR01DK138529 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Shingo Kajimura · 2024 to 2026
$2.1MMitochondrial NAD+ in Acute Myeloid LeukemiasR01CA272490 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI Xiaolu Ang Cambronne · 2023 to 2026
$2.1MMitochondrial BCAA transporter in physiology and diseaseR01DK125283 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2021 to 2025
$1.8MLocalized Real-time Sensors for Metabolic SignalingR35GM152218 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Xiaolu Ang Cambronne · 2024 to 2026
$1.1MNCI NIH HHS R01 CA272490NHLBI NIH HHS R01 HL165792NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK098656NIDDK NIH HHS R01 DK125283NIDDK NIH HHS R01 DK138529NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R35 GM152218Norges Forskningsråd (Research Council of Norway) 325172U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA272490U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK098656U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK125283U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK138529U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL165792U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM152218
Abstract
Nicotinamide adenine dinucleotide (NAD
Indexed as
HepatocytesLiver RegenerationMitochondriaMitochondria, LiverNADAnimalsMaleMiceMice, Inbred C57BLNAD
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.