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ArticleCardiovascular and interventional radiology2026

CT Hepatic Arteriography for Improved Detection and Ablation of Occult HCC Nodules: A Retrospective Analysis.

Riccardo Muglia, Carlotta Gargiulo, Francesco Saverio Carbone, Ludovico Dulcetta, Martina Bertuletti, Martijn Meijerink, Robbert Puijk, Bruno Calazans Odisio, Paolo Marra, Sandro Sironi

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Article in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Riccardo MugliaRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Carlotta GargiuloSchool of Medicine, University of Milano-Bicocca, Milan, Italy.
Francesco Saverio CarboneRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Ludovico DulcettaRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Martina BertulettiRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Martijn MeijerinkDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands.
Robbert PuijkDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands.
Bruno Calazans OdisioDepartment of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Texas, USA.
Paolo MarraRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. paolo.marra@unimib.it.ORCID http://orcid.org/0000-0003-4935-8110
Sandro SironiRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccurate preprocedural imaging is crucial for optimizing percutaneous thermal ablation of hepatocellular carcinoma (HCC) thermal ablation. However, some nodules may remain undetected using conventional contrast-enhanced CT (CECT) and MRI (CEMRI), due to poor conspicuity. CT hepatic arteriography (CTHA) is an imaging technique that improves the detection of primary/secondary liver tumors. We aimed to assess the diagnostic performance of CTHA in detecting occult HCC nodules in cirrhotic patients undergoing percutaneous microwave ablation and to evaluate its impact on pretreatment planning. MATERIALS AND

methodsThis retrospective, single-center study analyzed 38 CTHA-guided ablation procedures performed in 35 cirrhotic patients with confirmed HCC, from November 1, 2022, to December 31, 2024. All patients underwent preprocedural CECT /CEMRI within eight weeks before ablation. The number of additional nodules detected by CTHA and their suitability for immediate ablation were assessed.

resultsCTHA identified seven occult HCCs in 6/38 procedures (15.8%). The mean size of newly detected lesions was 13 mm (IQR 9). All additionally detected nodules were ablated during the same sessions. In 4/38 CTHAs (10.5%), vascular variants precluding a whole liver opacification were encountered. Technical success was achieved in 93.1% of all procedures, with a low rate of grade 1-3 complications (18.4%) and no severe ones. Eight treatments (21.6%) were followed by disease progression apart from the ablation zone.

conclusionCTHA enhances occult HCC detection, enabling immediate ablation and potentially improving outcomes. However, unusual vascular anatomy may hinder a comprehensive liver evaluation.

Indexed as

Carcinoma, HepatocellularComputed Tomography AngiographyLiver NeoplasmsAgedContrast MediaFemaleHumansMaleMiddle AgedRetrospective StudiesContrast MediaComputed tomographyCT hepatic arteriographyHepatocellular carcinomaMagnetic resonance imagingThermal ablation

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.