ArticleCommunications medicine2025
Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundMesial temporal lobe epilepsy (mTLE) is a common form of drug-resistant epilepsy and seizure outcomes after minimally invasive laser ablation remain suboptimal. Current imaging-guided strategies often fail to capture individual variability in seizure foci. This study aimed to develop a personalized neuroimaging biomarker to improve surgical planning and predict outcomes.
methodsThirty patients with mTLE (16 women, 53.3%; age range 17-59 years) who underwent magnetic resonance-guided laser interstitial thermal therapy were retrospectively analyzed. The asymmetry index (AI) from [
resultsHere we show that the AI of PET metabolic values significantly predicted seizure outcomes (odds ratio = 1.43, P = 0.02), with -0.06 as the threshold for defining pNMS (P for non-linearity = 0.04). A hippocampal pNMS ablative rate of 39.79% is significantly associated with seizure freedom (Pearson χ
conclusionsThe pNMS provides an individualized imaging marker for guiding laser ablation and predicting postoperative seizure outcomes. This approach supports more precise surgical planning and may improve long-term prognosis in patients with mesial temporal lobe epilepsy.
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