Evidence map›Paper›PMID 41266729›Full record

ArticleNature neuroscience2025

Behavioral devaluation by local resistance to dopamine.

Lauren E Miner, Aditya K Gautham, Michael A Crickmore

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lauren E MinerF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Aditya K GauthamF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Michael A CrickmoreF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. michael.crickmore@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-7175-4745

Funding

Use-Dependent Adjustments to Dopamine Reception in Motivational ControlR01NS140165 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Michael A Crickmore · 2025 to 2026
$1.1M
NINDS NIH HHS R01 NS140165U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS140165
6 · The paper itself

Abstract

Repeated experiences can cause behavior-specific fatigue. We use Drosophila to study this common form of motivational change, finding that prior matings make males more likely to abandon future copulations when challenged. Here we show that, during mating, dopamine signals through the D2-like receptor (D

Indexed as

CopulationDopamineMotivationReceptors, Dopamine D2Sexual Behavior, AnimalAnimalsAnimals, Genetically ModifiedDrosophilaDrosophila melanogasterDrosophila ProteinsFemaleMaleNeuronsDopamineDrosophila ProteinsReceptors, Dopamine D2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.