Evidence map›Paper›PMID 41266673›Full record

ArticleScientific reports2025

YY1-mediated transcriptional regulation of LINC01615 inhibits WNT2 mRNA degradation to promote gastric cancer progression.

Xiang Lin, Songyi Liu, Hui Chen, Ruofan He, Penghang Lin, Yan Lin, Xiaoyu Pan, Jianxin Ye, Guangwei Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiang Lin *Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Songyi Liu *Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Hui ChenDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Ruofan HeDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Penghang LinDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Yan LinDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Xiaoyu PanDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China.
Jianxin YeDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China. yejianxinfuyi@126.com.
Guangwei ZhuDepartment of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, 350005, Fuzhou, P.R. China. zgwzsy@126.com.

Funding

Fujian Province Eagle Plan Youth Top Talent Project SCYJHJRC-ZGW2024Fujian Provincial Health Technology Project 2020CXA032National Natural Science Foundation of China 82372958Natural Science Foundation of Fujian Province 2022J02032
6 · The paper itself

Abstract

Gastric cancer (GC) is a common malignancy of the digestive system, characterized by high invasiveness and metastasis, making it a leading cause of cancer-related deaths. Long non-coding RNAs (lncRNAs) play a crucial role in various types of cancer. This study aimed to elucidate the function of LINC01615 and its potential regulatory mechanisms in GC. In tissue and serum samples from GC patients, LINC01615 expression was significantly elevated and was associated with recurrence, distant metastasis, and TNM stage. LINC01615 promoted the proliferation, migration, and invasion of GC cells, and accelerated the growth of subcutaneous tumors in nude mice. Mechanistically, LINC01615 activated the WNT2/β-Catenin pathway by preventing WNT2 mRNA degradation and enhancing the nuclear translocation of β-Catenin. Furthermore, we identified the transcription factor YY1 as a key regulator of LINC01615 expression, which directly binds to its promoter region. Analysis of clinical samples revealed a positive correlation between the YY1/LINC01615/WNT2 signaling axis and poor prognosis in GC patients. Taken together, this study uncovers that the YY1/LINC01615/WNT2 signaling axis plays a crucial role in GC progression and may serve as a novel diagnostic marker and therapeutic target.

Indexed as

Gene Expression Regulation, NeoplasticRNA, Long NoncodingRNA, MessengerRNA StabilityStomach NeoplasmsWnt2 ProteinYY1 Transcription FactorAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleHumansMaleMiceRNA, Long NoncodingRNA, MessengerWnt2 ProteinWNT2 protein, humanYY1 protein, humanYY1 Transcription FactorGastric cancerLINC01615Long non-coding RNAWNT2YY1

Identifiers

PMID41266673
PMCPMC12635078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.