Evidence map›Paper›PMID 41266663›Full record

ArticleScientific reports2025

Cross sections of [Formula: see text]Sm([Formula: see text]Li,x) reactions for the production of [Formula: see text]Tb for targeted alpha therapy.

Laura A Bills, Alan B McIntosh, Jonathan T Morrell, Philip Adsley, Austin D Abbott, Diana Carrasco Rojas, Jeremias Garcia-Duarte, Matthew D Gott, Kris Hagel, Travis Hankins and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging Theranostic Radiometals (Pharmaceuticals (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Laura A BillsCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA. lamccan@tamu.edu.
Alan B McIntoshCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Jonathan T MorrellLos Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
Philip AdsleyCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Austin D AbbottCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Diana Carrasco RojasDepartment of Physics & Astronomy, Texas A&M University, College Station, Texas, 77843, USA.
Jeremias Garcia-DuarteLawrence Livermore National Laboratory, Livermore, California, 94550, USA.
Matthew D GottPhysics Division, Argonne National Laboratory, Lemont, Illinois, 60439, USA.
Kris HagelCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Travis HankinsCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Jason T HarkeLawrence Livermore National Laboratory, Livermore, California, 94550, USA.
Bryan M HarveyCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Richard O HughesLawrence Livermore National Laboratory, Livermore, California, 94550, USA.
Lauren A McIntoshCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Yonatan MishnayotLawrence Livermore National Laboratory, Livermore, California, 94550, USA.
Connor MohsPhysics Division, Argonne National Laboratory, Lemont, Illinois, 60439, USA.
Gabriela A PicayoDepartment of Chemistry, Texas A&M University, College Station, Texas, 77843, USA.
Madison ReuterCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Robert RiderCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
John SantucciCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Sophia SaucedaCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Maxwell SorensenCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Alexandra TabacaruCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Aaron S TamashiroLawrence Livermore National Laboratory, Livermore, California, 94550, USA.
Evgeny E TereshatovCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
David ThomasCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Zachary TobinCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
C Etienne VermeulenLos Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA.
Benjamin WellonsCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.
Sherry J YennelloCyclotron Institute, Texas A&M University, College Station, Texas, 77843, USA.

Funding

U.S. Department of Energy DE-FG02-93ER40773U.S. Department of Energy DE-SC0020958U.S. Department of Energy DE-SC0022550
6 · The paper itself

Abstract

Terbium-149g ([Formula: see text] = 4.12 h) is of particular interest for targeted alpha therapy cancer treatment due to its ability to decay via both alpha and positron emission, making it a potential theranostic nuclide. Due to many challenges facing its production, there are limited facilities worldwide that have demonstrated the ability to produce this nuclide in quantities sufficient for medical research. Since the Cyclotron Institute at Texas A&M University is a specialized accelerator facility capable of accelerating a wide variety of ions, we are investigating production pathway options. One of the major challenges facing its production is the known co-production of the excited isomeric state, [Formula: see text]Tb ([Formula: see text] = 4.1 min). However, this state does not decay to the ground state of [Formula: see text]Tb, negating any potential contribution to its yield. Due to its short-half life, the cross section for the population of this state has never been measured. After calculating several potential reaction yields using predictive models, the reactions of [Formula: see text]Sm([Formula: see text]Li,xn)[Formula: see text]Tb were identified as candidates. Lithium-6 beams of varied energies between 45-65 MeV were impinged on enriched [Formula: see text]Sm, [Formula: see text]Sm, and [Formula: see text]Sm targets at the Cyclotron Institute at Texas A&M University, and the reaction products were measured immediately following irradiation using high-purity germanium detectors, enabling detection of both [Formula: see text]Tb and [Formula: see text]Tb. Cross sections for all nuclides produced in sufficient activity in these reactions were also measured and reported here. We conclude that the population of [Formula: see text]Tb is much preferred over population of the ground state for these [Formula: see text]Li-induced reactions, and it is necessary to explore other options for [Formula: see text]Tb production.

Identifiers

PMID41266663
PMCPMC12635120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.