Evidence map›Paper›PMID 41266636›Full record

ArticleScientific reports2025

Attenuated cognitive control network connectivity as a mechanism in mother-daughter intergenerational transmission of depression: a preliminary study.

Katie L Burkhouse, Matthew B Thompson, Eda Naz Dinc, Noah H Kingston, Cope Feurer, Robert C Welsh, Ian H Gotlib, K Luan Phan, Scott A Langenecker

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Katie L BurkhouseDepartment of Psychology, Pennsylvania State University, 259 Moore Building, University Park, USA. klb5023@psu.edu.
Matthew B ThompsonDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, USA.
Eda Naz DincDepartment of Psychology, Pennsylvania State University, 259 Moore Building, University Park, USA.
Noah H KingstonDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, USA.
Cope FeurerDepartment of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, USA.
Robert C WelshCenter for Cognitive Neuroscience, University of California Los Angeles, Los Angeles, CA, USA.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, USA.
K Luan PhanDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, USA.
Scott A LangeneckerDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, USA.

Funding

Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent GirlsK23MH129564 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Cope Feurer · 2022 to 2026
$1.0M
Brain-Behavior Markers of Emotion in Depressed Mothers and Their DaughtersK23MH113793 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURKHOUSE, KATIE L · 2017 to 2021
$1.0M
NIH HHS K23-MH113793NIMH NIH HHS K23 MH113793NIMH NIH HHS K23 MH129564NIMH NIH HHS R37 MH101495NIMH NIH HHS R37MH101495
6 · The paper itself

Abstract

Identifying brain mechanisms implicated in the intergenerational transmission of major depressive disorder (MDD) is crucial for early detection and developing novel interventions. One promising mechanism involves altered intrinsic connectivity patterns in brain networks supporting emotion processing, including within the cognitive control network (CCN). The current preliminary study used resting state functional magnetic resonance imaging (fMRI) to examine whether altered CCN connectivity patterns are a brain-based mechanism of intergenerational risk for depression. We tested whether CCN connectivity patterns (1) differentiated mothers with and without recurrent MDD, (2) differentiated their high-risk (HR) and low-risk (LR) daughters, and (3) served as prospective predictors of daughters' depressive symptoms over a multi-wave follow-up. Participants were 56 mother-daughter pairs who completed a resting state fMRI scan. Mothers with, versus without, a history of MDD exhibited reduced connectivity between the CCN and other regions within the CCN, such as the middle frontal gyrus and dorsal anterior cingulate cortex (ACC). Reduced connectivity between the CCN and dorsal ACC was also observed in HR, relative to LR, daughters, correlated significantly among mothers and daughters, and associated with higher depression symptoms in daughters across 18 months. Reduced connectivity within the CCN may constitute one brain-based marker to further investigate as a target for prevention to attenuate the intergenerational transmission of depression.

Indexed as

BrainCognitionMajor Depressive DisorderMothersNerve NetAdultBrain MappingFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleMiddle AgedYoung AdultCognitive control networkIntergenerational riskMaternal depressionResting state connectivityYouth depression

Identifiers

PMID41266636
PMCPMC12635134

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.