Evidence map›Paper›PMID 41266629›Full record

ArticleNature aging2026

Reprogramming the GRHL2-CDK19 axis by gene therapy alleviates prostate aging.

Guoqiang Sun, Zan He, Dongliang Lv, Qiaoran Wang, Gang Xu, Feifei Liu, Peiyu Wang, Bilan Luo, Yandong Zheng, Jinghao Hu and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Guoqiang Sun *State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Zan He *Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital, Capital Medical University, Beijing, China.
Dongliang Lv *State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Qiaoran Wang *University of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-1886-4854
Gang XuLiver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu, China.
Feifei LiuBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Peiyu WangDepartment of Urology, The First Affiliated Hospital, Anhui Medical University, Anhui, China.
Bilan LuoAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yandong ZhengState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Jinghao HuAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital, Capital Medical University, Beijing, China.
Shuhui SunBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Shuai MaState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Concepcion Rodriguez EstebanAltos Labs San Diego Institute of Science, San Diego, CA, USA.
Jiayin YangLiver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0003-1623-551X
Xiaobing FuKey Laboratory of Tissue Repair and Regeneration of PLA, Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Medical Innovation Department, PLA General Hospital and PLA Medical College, Beijing, China.
Juan Carlos Izpisua BelmonteAltos Labs San Diego Institute of Science, San Diego, CA, USA.
Weiqi ZhangUniversity of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.ORCID http://orcid.org/0000-0002-8885-5104
Jing QuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.ORCID http://orcid.org/0000-0002-3988-5067
Si WangAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital, Capital Medical University, Beijing, China. wangsi@xwh.ccmu.edu.cn.ORCID http://orcid.org/0000-0003-2431-0612
Guang-Hui LiuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.ORCID http://orcid.org/0000-0001-9289-8177

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prostate is a multifunctional organ of the male reproductive system whose aging process impairs sexual and urinary function and fertility and increases disease susceptibility, thereby compromising quality of life. However, the mechanisms underlying human prostate aging remain poorly understood. Here we integrated single-nucleus transcriptomics and histological analyses to elucidate the aging mechanisms of the primate prostate. We identified epithelial cell senescence, chronic inflammation and fibrosis as key hallmarks of prostate aging. In young epithelial cells, GRHL2 promotes CDK19 transcription, which sequesters p53, leading to the suppression of p21

Indexed as

AgingCyclin-Dependent KinasesDNA-Binding ProteinsGenetic TherapyProstateTranscription FactorsAnimalsCellular SenescenceCyclin-Dependent Kinase Inhibitor p21Epithelial CellsHumansMaleTumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesDNA-Binding ProteinsGRHL2 protein, humanTranscription FactorsTumor Suppressor Protein p53

Identifiers

PMID41266629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.