Evidence map›Paper›PMID 41266578›Full record

ArticleScientific reports2025

Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment.

Gang Xiao, Min Fan, Kui Wang, Haonan Li, Yazhao Shen, Xufeng Cai, Haiyan Jiang, Guangling Wei, Haiyan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gang XiaoPower Metallurgy Research Institute, Central South University, Changsha City, 410083, Hunan Province, P.R. China.
Min FanDepartment of Pharmacy, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, 200003, P.R. China. fm04197@rjh.com.cn.
Kui WangNational Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China. fateratory@sjtu.edu.cn.
Haonan LiNational Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Yazhao ShenNational Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Xufeng CaiNational Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Haiyan JiangNational Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Guangling WeiNational Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China. weigl010@sjtu.edu.cn.
Haiyan YangShanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200240, China.

Funding

National Key Research and Development Program of China 2021YFB3501001National Natural Science Foundation of China 51804197Natural Science Foundation of Inner Mongolia Autonomous Region 2024MS05048
6 · The paper itself

Abstract

Effects of seven antihypertensives of Losartan Kalicum(LK), Atenolol(ATEN), Nifedipine(NF), Hydrochlorothiazide(HCTZ), Valsartan(VLA), Furosemide(FUR) and Captopril(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank's solution). LK, NF and HCTZ with the concentrations of 0.5, 1.0 and 0.5 g/L can remarkably enhance the degradation resistance of AZ31 alloy by 63.1, 69.4 and 70.5%, respectively. The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants.

Indexed as

AlloysAntihypertensive AgentsCaptoprilCorrosionDurapatiteMaterials TestingNifedipineSurface PropertiesValsartanAlloysAntihypertensive AgentsCaptoprilDurapatiteMg-Al-Zn-Mn-Si-Cu alloyNifedipineValsartanAntihypertensivesAZ31 alloyCorrosion filmDegradation rateHydroxyapatite

Identifiers

PMID41266578
PMCPMC12635266

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.