Evidence map›Paper›PMID 41266551›Full record

ArticleCommunications biology2025

A cross-sectional analysis of brain structure, pain behaviors, and mental health in persons with surgically confirmed endometriosis.

Maya L Jotwani, Edina Szabo, Gabriela Comptdaer, Ayeong Kim, Claire E Lunde, Meghan Pierce, Stacey A Missmer, Marc R Laufer, Ray Anchan, Rami Burstein and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maya L Jotwani *Biobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0000-5252-2191
Edina Szabo *Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Gabriela ComptdaerBiobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Ayeong KimBiobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Claire E LundeBiobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Meghan PierceTranslational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System, Boston, MA, USA.
Stacey A MissmerDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Marc R LauferBoston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6295-987X
Ray AnchanDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Center for Infertility and Reproductive Surgery, Harvard Medical School, Boston, MA, USA.
Rami BursteinDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
David BorsookDepartment of Anaesthesiology, Harvard Medical School, Boston, MA, USA.
Christine B SiebergBiobehavioral Pain Innovations Lab, Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Scott HolmesDepartment of Anesthesiology, Critical Care, Pain Medicine, Pain and Affective Neuroscience Center, Boston Children's Hospital, Boston, MA, USA. scott.holmes@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-5793-7983

Funding

Acquisition of a Siemens 3T MRI for Research ImagingS10OD025111 · OD · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2018 to 2018
$2.0M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) S10ODO25111NIH HHS S10 OD025111
6 · The paper itself

Abstract

Endometriosis is a highly prevalent and often painful gynecological condition that can emerge in adolescence and can be experienced throughout a person's lifetime. This cross-sectional investigation performed structural brain imaging and a battery of psychological and clinical tests on persons from adolescence (lowest age=12) to adulthood (highest age=44) with surgically confirmed endometriosis (SCE; n = 43) and persons never diagnosed with endometriosis and without report of pelvic pain (NDE; n = 26) to understand the impact of endometriosis associated pain on brain health. We observed an interaction wherein cortical thickness in the right superior frontal gyrus was negatively associated with age only in persons with SCE. A comparison of brain volumes demonstrated lower volume in the SCE group in the fusiform gyrus (left hemisphere) and lateral occipital cortex (right hemisphere). More research is required at the level of brain circuitry to understand the impact of endometriosis associated pain on the early and developed brain.

Indexed as

BrainEndometriosisMental HealthPelvic PainAdolescentAdultChildCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMiddle AgedYoung Adult

Identifiers

PMID41266551
PMCPMC12635101

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.