Evidence map›Paper›PMID 41266550›Full record

ArticleScientific reports2025

Nitric oxide modulates UDP-evoked cytosolic transients via P2Y

Talita Correa, Gioconda E D D Moura, Helena B Nader, Letícia Silva Ferraz, Ivarne L S Tersariol, Tiago Rodrigues, Fábio D Nascimento

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Talita CorreaDepartment of Biochemistry, Molecular Biology Division, Federal University of São Paulo (UNIFESP/EPM), Rua Três de Maio, 100, São Paulo, SP, CEP 09210-580, Brazil.
Gioconda E D D MouraDepartment of Biochemistry, Molecular Biology Division, Federal University of São Paulo (UNIFESP/EPM), Rua Três de Maio, 100, São Paulo, SP, CEP 09210-580, Brazil.
Helena B NaderDepartment of Biochemistry, Molecular Biology Division, Federal University of São Paulo (UNIFESP/EPM), Rua Três de Maio, 100, São Paulo, SP, CEP 09210-580, Brazil.
Letícia Silva FerrazDepartment of Biochemistry, Molecular Biology Division, Federal University of São Paulo (UNIFESP/EPM), Rua Três de Maio, 100, São Paulo, SP, CEP 09210-580, Brazil.
Ivarne L S TersariolDepartment of Biochemistry, Molecular Biology Division, Federal University of São Paulo (UNIFESP/EPM), Rua Três de Maio, 100, São Paulo, SP, CEP 09210-580, Brazil.
Tiago RodriguesNaturais E Humanas, Universidade Federal do ABC, UFABC. Avenida dos Estados, 5001. Bloco A, Torre 3, Sala 623, Santo André, SP, Brasil. tiago.rodrigues@ufabc.edu.br.ORCID http://orcid.org/0000-0003-1277-0224
Fábio D NascimentoDepartment of Biochemistry, Molecular Biology Division, Federal University of São Paulo (UNIFESP/EPM), Rua Três de Maio, 100, São Paulo, SP, CEP 09210-580, Brazil. fabio.dupart@unifesp.br.ORCID http://orcid.org/0000-0001-6672-3373

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/07464-4
6 · The paper itself

Abstract

Glycosaminoglycans (GAGs) and proteoglycans are key components of the extracellular matrix, playing structural and regulatory roles in various biological processes. GAGs are involved in modulating endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production. CHO-745 cells, deficient in GAGs, produce significantly higher NO levels than wild-type CHO-K1 cells. Since NO is crucial for vascular function, this study investigated how NO overproduction in GAG-deficient cells affects cytosolic Ca

Indexed as

CytosolNitric OxideReceptors, Purinergic P2Uridine DiphosphateAnimalsCalciumCalcium SignalingCHO CellsCricetinaeCricetulusEndoplasmic ReticulumEndoplasmic Reticulum StressGlycosaminoglycansOxidative StressType C PhospholipasesCalciumGlycosaminoglycansNitric Oxidepurinoceptor P2Y6Receptors, Purinergic P2Type C PhospholipasesUridine DiphosphateCalciumGlycosaminoglycansNitric oxideOxidative stressPurinergic receptors

Identifiers

PMID41266550
PMCPMC12635301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.