ArticleScientific reports2025
Evaluation of eco-friendly copper oxide nanoparticles for anticancer activity and antibacterial effects against Streptococcus mutans using molecular docking.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Remedial applications of biosynthesized metal oxide nanoparticles against pathogenic microorganisms.Discover nano · 2026Review
- Copper/Copper Oxide Nanoparticles: Biological Synthesis, Characterization and Potential Biomedical Applications: Advances and Perspectives.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Therapeutic horizons of cuproptosis: bibliometric mapping of copper-dependent cell death research and its pharmacological implications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Foliar application of green-synthesized Cu-Zn nanocomposites: improve physiological responses, isozymes activity, and photosynthetic traits in lead-stressed pea (Pisum sativum L.) plants.Scientific reports · 2026Article
- Phyto mediated synthesis of copper oxide nanoparticles with Zingiber officinale: comprehensive bioactivity assessment against bacterial pathogens, cancer, and viruses.BMC biotechnology · 2026Article
- Green-Synthesized Copper and Copper Oxide Nanoparticles: Structural Characterization and Evaluation of Biological Activity.Antioxidants (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since copper oxide nanoparticles (CuO-NPs) have antibacterial qualities, they are extremely helpful in many disciplines, including medicine. Utilizing data from FTIR, zeta potential, DLS, EDX, SEM, and UV-vis, the characteristics of the generated CuO-NPs were examined. CuO-NPs were found to have a spherical form, a surface charge of - 32.5 mV, and a maximum absorbance at 260 nm. Utilizing various methods, the produced CuO-NPs were tested for their antibacterial and anticancer qualities. On agar plates, CuO-NPs made from Mentha spicata leaf extract show fatal activity against Streptococcus mutans ATCC 25175 at high doses (0.5 mg/mL) includes a 16 mm diameter inhibitory zone. For CuO-NPs, the MIC was found to be 0.25 mg/mL. Furthermore, A dosage of 0.0625 mg/mL CuO-NPs was effective against the biofilm formation of S. mutans ATCC 25175 without affecting the growth of planktonic cells. Based on the findings, the dihydroorotase synthase (DHPR) may be partially or fully responsible for the activity, with the primary interaction seen being the hydrophobic contact with the amino acid residues in the pocket's active site. It was demonstrated that CuO-NPs reduced OECM-1 cancer cells by 95.8% at a dose of 62.5 μg/mL. It was found that CuO-NPs had an IC
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