Evidence map›Paper›PMID 41266425›Full record

ArticleNPJ biofilms and microbiomes2025

Dual chitosan hydrogel and polylactic acid microparticle delivery system reduces Staphylococcal osteomyelitis and soft tissue infection.

Luke J Tucker, Xavier J Person, Julia M DiFiore, Bailey E Roux, Malley A Gautreaux, Lauren B Priddy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luke J TuckerDepartment of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS, USA.
Xavier J PersonDepartment of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS, USA.
Julia M DiFioreCollege of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.
Bailey E RouxDepartment of Biochemistry, Nutrition, and Health Promotion, Mississippi State University, Mississippi State, MS, USA.
Malley A GautreauxDepartment of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS, USA.
Lauren B PriddyDepartment of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS, USA. Lbpriddy@abe.msstate.edu.

Funding

Zinc dependent conformational changes in AdcR and their impact on DNA bindingP20GM103646 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI THIBAUDEAU, GISELLE · 2013 to 2022
$21.1M
Summer Research Experience for Veterinary StudentsT35OD010432 · OD · MISSISSIPPI STATE UNIVERSITY · PI Barbara Lee-Faubert Kaplan, Temesgen Samuel · 2012 to 2026
$1.3M
Center of Biomedical Research Excellence (COBRE) in Pathogen-Host Interactions P20GM103646Congressionally Directed Medical Research Programs W81XWH-21-1-0193NIGMS NIH HHS P20 GM103646NIH HHS T35 OD010432NIH HHS T35OD010432
6 · The paper itself

Abstract

Osteomyelitis, an infection of bone, is traditionally treated with long-term, systemic, high-dose antibiotics, which can lead to kidney and liver damage and accelerate the development of antibiotic resistance. Localized delivery may mitigate these risks by delivering antimicrobial(s) directly to the site of infection. Herein, innately antimicrobial chitosan hydrogel (CH) containing polylactic acid (PLA) microparticles, each loaded with fosfomycin antibiotic, was used to combat a biofilm-forming strain of Staphylococcus aureus. This dual CH + PLA biomaterial treatment mitigated S. aureus in planktonic and biofilm form in vitro, and in a clinically relevant, implant-associated rat model of chronic osteomyelitis. Notably, only the CH + PLA biomaterial treatment led to a reduction in bone defect area, plasma haptoglobin level, and bacterial burden in bone and soft tissue, compared to hydrogel only. Local treatment of osteomyelitis with the chitosan+microparticle vehicle loaded with fosfomycin mitigated S. aureus pathogenesis and may serve as an effective alternative to systemic antibiotics.

Indexed as

ChitosanFosfomycinOsteomyelitisPolyestersSoft Tissue InfectionsStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsBacterial LoadBiofilmsDisease Models, AnimalDrug Delivery SystemsFemaleHydrogelsInjections, IntraperitonealMicrobial Sensitivity TestsAnti-Bacterial AgentsChitosanFosfomycinHydrogelsPolyesterspoly(lactide)

Identifiers

PMID41266425
PMCPMC12635059

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.