Evidence map›Paper›PMID 41266383›Full record

ArticleNature communications2025

Implantable bioelectronics for gut electrophysiology.

Alexander J Boys, Amparo Güemes, Liang Ma, Rohit A Gupta, Zixuan Lu, Chaeyeon Lee, Salim El-Hadwe, Alejandro Carnicer-Lombarte, Tobias E Naegele, Friederike Uhlig and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexander J Boys *Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6488-7005
Amparo Güemes *Department of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4206-6812
Liang MaDepartment of Electrical Engineering, University of California, Irvine, CA, USA.
Rohit A GuptaDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2958-1526
Zixuan LuDepartment of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3689-4283
Chaeyeon LeeDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7633-2448
Salim El-HadweDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5521-524X
Alejandro Carnicer-LombarteDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5650-4692
Tobias E NaegeleDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1842-6750
Friederike UhligDepartment of Physiology, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0001-7441-1951
Damiano G BaroneDepartment of Engineering, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0091-385X
David C BulmerDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Jennifer N GelinasDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-1164-638X
Niall P HylandDepartment of Physiology, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0003-0060-7390
Dion KhodagholyDepartment of Electrical Engineering, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-0805-4612
George G MalliarasDepartment of Engineering, University of Cambridge, Cambridge, UK. gm603@cam.ac.uk.ORCID http://orcid.org/0000-0002-4582-8501
Róisín M OwensDepartment of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK. rmo37@cam.ac.uk.ORCID http://orcid.org/0000-0001-7856-2108

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
DH | National Institute for Health Research (NIHR) NI~HR203312Human Frontier Science Program (HFSP) LT000034-C/2020NCI NIH HHS P30 CA023108RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/S009000/1RCUK | MRC | Medical Research Foundation MC_UU_00014/5Royal Academy of Engineering RF-2324-23-284Science Foundation Ireland (SFI) 12/RC/2273_P2Science Foundation Ireland (SFI) 22/PATH/S-10882
6 · The paper itself

Abstract

A major regulator of gastrointestinal physiology is the enteric nervous system. This division of the autonomic nervous system is unique in its extensiveness, with neurons distributed from the esophagus to the rectum, and its capability for local information processing. However, the constant motion of the gut, arising from its relative movements in the peritoneal cavity and the peristaltic movements associated with gut motility, as well as the sparse distribution of the neurons constituting the enteric nervous system, has made access and analysis exceedingly challenging. Here, we present the construction and validation of a bioelectronic implant for accessing neural information from the distal colon. Our bioelectronic monitoring system demonstrates real-time electrophysiological recording in response to chemical and mechanical distension under anesthesia and to feeding and stress in freely-moving animals. Direct access to the communication pathways of the enteric nervous system paves the way for neuromodulation strategies targeting the gut-brain axis.

Indexed as

ColonElectrophysiologyEnteric Nervous SystemProstheses and ImplantsAnimalsElectrodes, ImplantedElectrophysiological PhenomenaGastrointestinal MotilityMaleNeuronsRats

Identifiers

PMID41266383
PMCPMC12635400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.