Articlenpj aging2025
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo.
Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Prenatal and Postnatal Determinants of Outcome in Neonates with Omphalocele: A 25-Year Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- Skipjack tuna bone derived biocalcium ameliorates C2C12 myotube atrophy through microRNA29b regulation.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Collagen supplementation has gained attention with increasing claims regarding its beneficial effects on healthy aging based on clinical observations and lifespan extension in pre-clinical models; however, how and which part of an ingested collagen promotes healthy longevity is unknown. Here, we identified the minimal required unit of ingested collagen, which consists of the proper ratio of three glycine to one proline to one hydroxyproline that was sufficient to increase the motility-healthspan and lifespan of C. elegans, as well as collagen homeostasis in human fibroblasts in vitro. Supplementation in 20-month-old mice improved grip strength and prevented age-related fat accumulation. In a clinical observational trial (ISRCTN93189645, 03.07.2025), oral supplementation in humans demonstrated improved skin features within three months and a reduction in biological age by 1.4 years (p = 0.04) within 6 months. Thus, a ratio of three amino acids elicits evolutionarily conserved health benefits from ingested collagens.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.