Evidence map›Paper›PMID 41266363›Full record

Articlenpj aging2025

Prolonged intermittent hypoxia accelerates cardiovascular aging and mortality: insights from a murine model of OSA.

Mohammad Badran, Clementine Puech, David Gozal

Abstract read
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammad BadranDepartment of Pediatrics, University of Missouri, Columbia, MO, USA. mbadran@health.missouri.edu.
Clementine PuechDepartment of Pediatrics, University of Missouri, Columbia, MO, USA.
David GozalDepartment of Pediatrics and Office of the Dean, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA. gozal@marshall.edu.

Funding

Coronary artery dysfunction in OSA: Role of mineralocorticoid receptorsR01HL166617 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Mohammad Badran · 2023 to 2026
$2.5M
NHLBI NIH HHS HL166617NHLBI NIH HHS R01 HL166617
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) accelerates cardiovascular aging through intermittent hypoxia (IH). We exposed mice to 22 months of IH, modeling lifelong OSA. Compared to controls, IH mice exhibited higher mortality, elevated blood pressure, impaired systolic and diastolic function, vascular stiffening, reduced coronary reserve, and ECG abnormalities. These findings suggest that chronic IH significantly exacerbates cardiovascular decline with aging, underscoring the importance of early OSA diagnosis and intervention.

Identifiers

PMID41266363
PMCPMC12635055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.