ArticleTranslational psychiatry2025
Subtypes of cocaine use disorder and their neurobehavioral profiles.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Repeated measures latent class analysis identifies unique daily cocaine-use patterns and associated clinical characteristics: A timeline followback-based analytic approach.Drug and alcohol dependence reports · 2026Article
- Neurobiological subtypes in alcohol use disorder and their phenotypic and clinical profiles.Molecular psychiatry · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Cocaine Use Disorder (CUD) afflicts over 1.4 million individuals in the United States alone. However, current treatments are largely ineffective, with up to 85% returning to use long-term. We posit that addressing functional heterogeneity underlying CUD is crucial for improving treatment success. Based on prior work, we hypothesized heterogeneity in function across three domains: approach-related behavior, executive function, and negative emotionality. We analyzed data from 109 participants (ages 22-39, 15% female, N = 61 CUD) from the SUDMEX CONN dataset. To test if distinct 'mechanism-based' subtypes exist within CUD, we conducted a Latent Profile Analysis using phenotypic data as input. The discovered subtypes were characterized regarding their use characteristics, psychiatric diagnostics, and resting-state functional connectivity (rsFC). Three distinct subtypes emerged (p < 0.05, partial eta squared: 0.19-0.51): a 'Relief Type' with high negative emotionality (N = 22); a 'Cognitive Type' with lower executive function (N = 15); and an 'Undefined Type' with no apparent impairments (N = 24). Consistent with this profile, the Relief Type had more comorbid psychiatric diagnoses. Furthermore, each subtype demonstrated a unique neurobiological profile underlying their current cocaine use (p
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