Evidence map›Paper›PMID 41266335›Full record

ArticleNature communications2025

Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study.

Haiyan Zhao, Binglei Zhao, Jiajun He, Manhua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haiyan Zhao *MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China.
Binglei Zhao *School of Psychology, Shanghai Jiao Tong University, Shanghai, P. R. China. binglei.zhao@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-5390-1983
Jiajun HeBiomedical Engineering Department, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0008-4908-7019
Manhua LiuMoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China. mhliu@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-6496-670X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The entorhinal cortex (EC) is known to play important roles in spatial cognition of human behaviors. However, the functional contributions and the lateralization of EC are not well known. This paper proposed a new paradigm by employing non-invasive stimulation - Temporal interference (TI) - of human EC in left or right hemisphere under path integration (PI) tasks of sensory-driven and abstract processing. Five metrics were introduced to evaluate PI performance, with results revealing significant improvements after EC stimulation. Moreover, the left EC modulation achieved more enhanced performances of abstract processing, whereas the modulation of the right EC had better improvements in the sensory-driven condition. The results indicated that functional roles may differ in left and right EC under PI tasks. This study provided valuable insights into hemispheric specialization within EC and suggested potential pathways for developing early intervention strategies through the non-invasive modulation of EC.

Indexed as

Entorhinal CortexFunctional LateralityAdultCognitionFemaleHumansMaleYoung Adult

Identifiers

PMID41266335
PMCPMC12635200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.