ArticleNature communications2025
Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults.
Maggie A Stanislawski, Elizabeth Litkowski, Christopher H Arehart, Kai Luo, Niles Gilmore, Leslie A Lange, Ethan M Lange, Kathleen Barnes, Christy L Avery, Katie A Meyer and 4 more
Abstract read
In one paragraphArticle in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Niles GilmoreDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Leslie A LangeDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Ethan M LangeDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Kathleen BarnesDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Katie A MeyerDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Fernando HolguinDepartment of Medicine, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Funding
NHLBI Data Stage Coordinating CenterOT3HL147154 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ashok Kumar Krishnamurthy · 2018 to 2026
$98.9MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MDIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0MNew York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8MEpidemiology of the gut microbiome, prediabetes and diabetes in LatinosR01MD011389 · NIMHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BURK, ROBERT D, KAPLAN, ROBERT C · 2016 to 2020
$4.3MUltra-processed Foods, Diet Quality, and Cardiometabolic Health: An Inter-disciplinary Trans-Atlantic Collaborative ProjectR01DK120870 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Qibin Qi, Qi Sun · 2019 to 2026
$4.2MParkin in mitochondrial dysfunction and airway inflammation of obese asthmaR01AI152504 · NIAID · NATIONAL JEWISH HEALTH · PI CHU, HONG W, HOLGUIN, FERNANDO · 2020 to 2024
$3.7MIntegrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolitesR01HL140976 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, KNIGHT, ROB · 2018 to 2021
$3.3MCardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS)R01HL136266 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, MOSSAVAR-RAHMANI, YASMIN · 2017 to 2020
$3.1MLIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmaticsR33HL157069 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Stacy Lynn Gelhaus, Fernando Holguin · 2023 to 2026
$3.0MMetabolomics signatures underlying diet, lifestyle and gut microbiota for diabetesR01DK119268 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI QI, QIBIN · 2019 to 2022
$2.4MNHLBI NIH HHS K01 HL157658NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS OT3 HL147154NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL136266NHLBI NIH HHS R01 HL140976NHLBI NIH HHS R33 HL157069NHLBI NIH HHS R61 HL157069NIAID NIH HHS R01 AI152504NIA NIH HHS R01 AG085320NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK119268NIDDK NIH HHS R01 DK120870NIDDK NIH HHS R01 DK134672NIMHD NIH HHS R01 MD011389U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1OT3HL14715U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HHSN268200625235CU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL157658U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL136266U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL157069U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AI152504U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD) R01MD011389
6 · The paper itselfAbstract
Asthma is a heterogeneous condition that is often comorbid with obesity and influenced by diverse risk factors. Elucidating the association of gut microbial characteristics with asthma could improve our understanding of the pathophysiology. Here, we investigate relationships of host genetics and stool microbiota characteristics with asthma among US Hispanic/Latino adults, while considering the influence of obesity status, using host whole genome sequencing and stool shotgun metagenomic microbiota data from participants of the Hispanic Community Health Study/Study of Latinos. We evaluate cross-sectional associations of microbiota characteristics with asthma and analyse whether they are modified by obesity status (body mass index≥30 kg/m
Indexed as
AsthmaGastrointestinal MicrobiomeHispanic or LatinoAdultBody Mass IndexCross-Sectional StudiesFecesFemaleHumansMaleMiddle AgedObesityRisk FactorsUnited States
Identifiers
PMID41266326
PMCPMC12635389
What OpenQuestion holds
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