Evidence map›Paper›PMID 41266314›Full record

ArticleTranslational psychiatry2025

Modulation of reward positivity and blink rate in children with attention deficit hyperactivity disorder (ADHD) during and following transcranial direct current stimulation.

Jasper Vöckel, Lena Pokorny, Rebecca Rossberg, Nina Geist, Anne Kühnel, Nils B Kroemer, Divya Seernani, Christoph Klein, Stephan Bender

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jasper VöckelDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. jasper.voeckel@uk-koeln.de.ORCID http://orcid.org/0000-0002-6306-3346
Lena PokornyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-5638-0813
Rebecca RossbergDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Nina GeistDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Anne KühnelSection of Medical Psychology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-3066-3801
Nils B KroemerSection of Medical Psychology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-9552-3781
Divya SeernaniiMotions A/S, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7125-9058
Christoph KleinDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Stephan BenderDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-8199-3785

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SFB 1451 - Project-ID 431549029
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) over the right pre-frontal cortex has been found to increase striatal dopaminergic activity and modulate dopaminergic dependent behavior. However, it remains to be elucidated to what extent this tDCS set-up is effective in changing reward system activation in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Twenty-four children and adolescents with ADHD received both, 2 mA and sham tDCS. The anode was positioned over the ventromedial prefrontal-cortex (PFC), while the cathode was placed over the right dorsolateral PFC. During and after tDCS, participants performed an effort allocation task aimed at earning monetary rewards. Concurrent with task performance, the reward positivity (RewP) and blink rate were assessed using electroencephalography and eye tracking. Both markers may be influenced by striatal dopamine levels. We found an increase in RewP after tDCS compared to sham (b = 0.65; p = 0.010), but no significant difference during stimulation. No significant differences were found for tDCS-related changes in blink rate during or after stimulation. tDCS with an anode over the vmPFC and cathode over the rDLPFC increases RewP after stimulation in children and adolescents with ADHD, which may be related to tDCS effects on reward processing.

Indexed as

Attention Deficit Disorder with HyperactivityBlinkingPrefrontal CortexRewardTranscranial Direct Current StimulationAdolescentChildDopamineElectroencephalographyFemaleHumansMaleDopamine

Identifiers

PMID41266314
PMCPMC12669705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.