Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase.

Krisna Prak, Christin Luft, Eliona Tsefou, Carlos Chávez-Olórtegui, Janos Kriston-Vizi, Robin Ketteler, Vania M M Braga

Abstract read

In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

7 authors.

Krisna PrakNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.

Christin LuftLaboratory for Molecular Cell Biology, University College London, London, UK.

Eliona TsefouLaboratory for Molecular Cell Biology, University College London, London, UK.

Carlos Chávez-OlórteguiBiochemistry and Immunology Department, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Janos Kriston-ViziLaboratory for Molecular Cell Biology, University College London, London, UK.

Robin KettelerLaboratory for Molecular Cell Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-2786-7291

Vania M M BragaNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK. v.braga@imperial.ac.uk.ORCID http://orcid.org/0000-0003-0546-7163

Funding

Wellcome Trust

6 · The paper itself

Abstract

Snakebite accidents are prevalent worldwide and cause a spectrum of severe clinical manifestations and result in a reduction of patient quality of life and economic income. A major bottleneck in envenomation treatment is our limited understanding of how venom toxins perturb specific cellular processes involved in tissue necrosis. Here, we address this knowledge gap and define the cellular mechanisms via which cell death is triggered by the snake toxin L-amino acid oxidase (LAAO). LAAO is a highly toxic enzyme present in various venoms that causes tissue necrosis, edema, coagulopathies, and organ failure. Here, we identify the residues essential for LAAO oxidation and obtain a catalytically inactive LAAO mutant, which is unable to reproduce the cellular phenotypes. Striking cellular defects are triggered by a catalysis-dependent increase in oxidative stress, via H

Indexed as

L-Amino Acid OxidaseAnimalsAutophagyCell DeathHumansHydrogen PeroxideLysosomesMitochondriaMitochondrial DynamicsOxidation-ReductionOxidative StressHydrogen PeroxideL-Amino Acid Oxidase

Identifiers

PMID41266304

DOI10.1038/s41419-025-08187-7

PMCPMC12811378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.