ArticleACS applied materials & interfaces2025
Nano-PhotoCrystals (Photosensitive Nanocrystals) of Aloe Emodin Combined with Dissolving Microneedles for Dual Smart Targeting of Acute Bacterial Skin and Soft Tissue Infections.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute bacterial skin and soft tissue infections (ABSSTIs) are often treated with antibiotics, facing challenges with off-target toxicity and limited tissue penetration, with inadequate treatment escalating into serious conditions requiring hospitalization. Photodynamic antibacterial therapy (PACT), employing natural photosensitizers (PS), presents a promising alternative but is limited by poor water solubility, with modification strategies restricted by limited loading efficiency and drug release due to quenching effects (e.g., liposomes). To this end, this study explores the utilization of a matrix-free system, introducing the novel preparation of photosensitive nanocrystals (i.e., nanosized photosensitizers) referred to as nano-PhotoCrystals, derived from aloe emodin (AE), an anthraquinone naturally found in
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