Evidence map›Paper›PMID 41266256›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Modifiable Factors Associated with the Longitudinal Increase and Spatial Extent of Tau Pathology in Alzheimer Disease.

Merle C Hoenig, Verena Dzialas, Elena Doering, Gérard N Bischof, Thilo van Eimeren, Alexander Drzezga, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Merle C HoenigInstitute for Neuroscience and Medicine II, Molecular Organization of the Brain, Research Center Juelich, Juelich, Germany; m.hoenig@fz-juelich.de.
Verena DzialasFaculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
Elena DoeringInstitute for Neuroscience and Medicine II, Molecular Organization of the Brain, Research Center Juelich, Juelich, Germany.
Gérard N BischofFaculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
Thilo van EimerenFaculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
Alexander DrzezgaInstitute for Neuroscience and Medicine II, Molecular Organization of the Brain, Research Center Juelich, Juelich, Germany.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

There are 14 modifiable factors that are associated with a significantly lower risk of dementia. We tested the interactive effect of modifiable factors, genetic determinants, and initial pathologic burden on the spatial progression and local amplification of tau pathology.

Indexed as

Alzheimer Diseasetau ProteinsAgedAged, 80 and overBody Mass IndexCarbolinesFemaleHumansLongitudinal StudiesMaleMiddle AgedPositron-Emission TomographyRisk Factors7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinestau Proteins(non-)modifiable risk factorsspatial extenttau pathology

Identifiers

PMID41266256
PMCPMC12866421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.