Evidence map›Paper›PMID 41266087›Full record

ArticleGenes & development2026

B-lineage commitment is dependent on a reversible epigenetic switch.

Johanna Tingvall-Gustafsson, Kim Hellerstedt, Jonas Ungerbäck, Mikael Sigvardsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Johanna Tingvall-GustafssonDepartment of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden.ORCID 0000-0002-7359-6584
Kim HellerstedtDepartment of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden.
Jonas UngerbäckDivision of Molecular Hematology, Lund University, 22362 Lund, Sweden.
Mikael SigvardssonDepartment of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden; mikael.sigvardsson@liu.se.ORCID 0000-0001-8527-7276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To increase our understanding of the interplay between transcription factor networks and the epigenetic landscape in early B-lymphoid development, we conducted combined SC-RNA/ATAC-seq analyses of bone marrow progenitor populations. Based on changes in DNA accessibility, we created a high-resolution model for B-cell development. Trend change analysis identified a rapid shift in DNA accessibility, resulting in the loss of T-lineage priming and the acquisition of the epigenetic landscape of B-lymphocytes in association with the activation of the B-lineage program. The epigenetic switch correlated strongly with the initiation of

Indexed as

B-LymphocytesCell LineageEpigenesis, GeneticAnimalsCell DifferentiationEnhancer of Zeste Homolog 2 ProteinMiceMice, Inbred C57BLPAX5 Transcription FactorPolycomb Repressive Complex 2Signal TransductionT-LymphocytesTrans-ActivatorsEbf1 protein, mouseEnhancer of Zeste Homolog 2 ProteinEzh1 protein, mouseEzh2 protein, mousePax5 protein, mousePAX5 Transcription FactorPolycomb Repressive Complex 2Trans-ActivatorsB-lymphocytesepigeneticstranscription

Identifiers

PMID41266087
PMCPMC12863259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.