Epigenetic Regulation in Dilated Cardiomyopathy.

Chia-Feng Liu, Steven Leon, W H Wilson Tang

Abstract readReview

In one paragraph

Review in Heart failure clinics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chia-Feng LiuDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Mail code NC10, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.

Steven LeonDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Mail code NC10, Cleveland, OH 44195, USA.

W H Wilson TangDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Mail code NC10, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Kaufman Center for Heart Failure Treatment and Recovery, Heart Vascular and Thoracic Institute, Cleveland Clinic, Mail code J3-4, Cleveland, OH 44195, USA. Electronic address: tangw@ccf.org.

Funding

International Consortium for Multimodality Phenotyping in Adults with Non-compactionR01HL146754 · NHLBI · STANFORD UNIVERSITY · PI NIEMAN, KOEN, TANG, WAI HONG WILSON · 2020 to 2023

$3.0M

NHLBI NIH HHS R01 HL146754

6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM) is a nonischemic heart muscle disease characterized by impaired contractility, cardiac dilation, and heart failure, with both genetic and nongenetic causes. Emerging evidence highlights epigenetic mechanisms, including deoxyribonucleic acid methylation, histone modifications, chromatin remodeling, and noncoding RNAs, as critical regulators of gene expression in DCM pathogenesis. This article explores familial DCM linked to pathogenic variants in genes like lamin A/C and titin, as well as nongenetic forms such as diabetic and autoimmune DCM. By summarizing recent discoveries, it highlights the epigenetic factors in bridging genetic and environmental influences, offering potential biomarkers and therapeutic targets for improved DCM management.

Indexed as

Cardiomyopathy, DilatedEpigenesis, GeneticConnectinDNA MethylationHumansConnectinDiabetic cardiomyopathy autoimmune DCMDilated cardiomyopathyEpigeneticLMNA

Identifiers

PMID41265985

DOI10.1016/j.hfc.2025.08.002

PMCPMC13549136

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.