Evidence map›Paper›PMID 41265927›Full record

ArticleBMJ global health2025

Design and implementation of a drug revolving fund for hypertension treatment in primary care setting of the Federal Capital Territory, Nigeria.

Grace Julcit Shedul, Eugenia N Ugwuneji, Erica L Jamro, Bolanle Banigbe, Patrick Ponzing, Inuwa Okpe, Nanna R Ripiye, Ikechukwu A Orji, Gabriel Lamkur Shedul, Samuel Osagie and 7 more

Abstract read
In one paragraph

Article in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Grace Julcit ShedulPharmacy, University of Abuja Teaching Hospital, Gwagwalada, Nigeria shedulinks@gmail.com.ORCID http://orcid.org/0000-0002-9277-3208
Eugenia N UgwunejiCardiovascular Research Unit, University of Abuja, Abuja, Nigeria.
Erica L JamroCardiovascular Division and Global Health Center, Washington University in St Louis, St Louis, Missouri, USA.ORCID http://orcid.org/0000-0003-3431-9653
Bolanle BanigbeResolve to Saves Lives, New York, New York, USA.
Patrick PonzingPharmacy, University of Abuja Teaching Hospital, Gwagwalada, Nigeria.
Inuwa OkpePharmacy, University of Abuja Teaching Hospital, Gwagwalada, Nigeria.
Nanna R RipiyeCardiovascular Research Unit, University of Abuja, Abuja, Nigeria.
Ikechukwu A OrjiCardiovascular Research Unit, University of Abuja, Abuja, Nigeria.
Gabriel Lamkur ShedulCardiovascular Research Unit, University of Abuja, Abuja, Nigeria.ORCID http://orcid.org/0000-0003-2295-908X
Samuel OsagieCardiovascular Research Unit, University of Abuja, Abuja, Nigeria.
Abigail S BaldridgeBluhm Cardiovascular Institute, Northwestern Medicine, Chicago, Illinois, USA.ORCID http://orcid.org/0000-0002-1573-0554
Namratha R KandulaHavey Institute of Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Okeoma ErojikweResolve to Saves Lives, New York, New York, USA.
Mark D HuffmanThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Dike OjjiCardiovascular Research Unit, University of Abuja, Abuja, Nigeria.
Lisa R HirschhornMedical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID http://orcid.org/0000-0002-4355-7437
Hypertension Treatment in Nigeria Programme Investigators

Funding

Transforming Hypertension Management in NigeriaR01HL144708 · NHLBI · WASHINGTON UNIVERSITY · PI Mark D Huffman, Dike Bevis Ojji · 2019 to 2026
$4.3M
Cardiovascular Research Training In Nigeria (CeRTIN)D43TW011976 · FIC · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Lisa Hirschhorn, Mark D Huffman · 2021 to 2026
$1.4M
FIC NIH HHS D43 TW011976NHLBI NIH HHS R01 HL144708
6 · The paper itself

Abstract

backgroundExpanding treatment for hypertension requires ensuring access to affordable, high-quality blood pressure (BP) lowering medications. We describe the design, implementation and evaluation of a BP-lowering medication drug revolving fund (DRF) embedded in the Hypertension Treatment in Nigeria (HTN) Programme in 60 primary healthcare centres (PHCs) in the Federal Capital Territory, Nigeria.

methodsWe used the exploration, preparation, implementation and sustainment framework to describe the DRF design and implementation and the reach, effectiveness, adoption, implementation and maintenance framework to report implementation outcomes. From June 2022 to December 2023, the DRF programme was implemented, and the data were collected from PHCs' drug stock and finance records, quarterly DRF-supportive supervision visits and the HTN Programme. We performed descriptive statistics using complete case analysis and used an interrupted time-series design to explore temporal trends in the 3-month rolling average rate of BP-lowering prescriptions dispensed.

resultsDRF design and implementation strategies included stakeholder engagement, leveraging the existing supply systems, developing medication and financial management protocols, training of site staff and DRF-supportive supervision visits, including joint problem solving. DRF was implemented in all 60 PHCs (100% reach). Adoption was high, with an increase in facilities selling DRF-supported medications from 80% to 100% (p value=0.01). Fidelity improved, including correct financial documentation (70%-100%; p value<0.0001) and stock cards (68%-94%; p value=0.0004). Effectiveness was high with low rates of medication stockouts of DRF-supported medications (1.7%-16%), with most medications at affordable prices, but a 12.1% drop in BP-lowering medications dispensing rate when the DRF replaced study-supplied free medication. Maintenance was high, with 100% of PHCs having a functional DRF after 1 year.

conclusionA DRF programme to expand access to BP-lowering medications was implemented and effective in the Federal Capital Territory, Nigeria, and may serve as a model for other hypertension control programmes.

Indexed as

Antihypertensive AgentsHypertensionPrimary Health CareHumansNigeriaAntihypertensive AgentsCardiovascular diseaseDescriptive studyGlobal HealthHealth services researchHypertension

Identifiers

PMID41265927
PMCPMC12636893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.