Evidence map›Paper›PMID 41265704›Full record

ArticleJournal of molecular and cellular cardiology2026

Sphingosine-1-phosphate activates I

Frank J Raucci, Adolfo G Mauro, Edward J Lesnefsky, Clive M Baumgarten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frank J RaucciDepartment of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA; Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address: frank.raucci@vcuhealth.org.
Adolfo G MauroDivision of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University Health System, Richmond, VA, USA.
Edward J LesnefskyDepartment of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA; Division of Cardiology, Department of Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA; Medical Service, McGuire Veterans Affairs Medical Center, Richmond, VA, USA.
Clive M BaumgartenDepartment of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA.

Funding

Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne CardiomyopathyK08HL155852 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI RAUCCI, FRANK J · 2021 to 2025
$742k
BLRD VA I01 BX001355NHLBI NIH HHS K08 HL155852
6 · The paper itself

Abstract

aimsWe previously demonstrated that bacterial sphingomyelinase (SMase), which converts plasmalemmal sphingomyelin to long-chain ceramides, activates the swelling-activated chloride current (I METHODS AND

resultsWhole-cell patch clamp experiments were conducted using freshly isolated rabbit ventricular myocytes. Inhibition of ceramidase with D-erythro-MAPP, which increases the concentration of endogenous ceramides in the cell membrane, prevented activation of I

conclusionsTaken together, these data suggest S1P is the sphingolipid that triggers I TRANSLATIONAL PERSPECTIVE: I

Indexed as

Chloride ChannelsHeart VentriclesLysophospholipidsMitochondriaMitochondria, HeartMyocytes, CardiacReactive Oxygen SpeciesSphingosineAnimalsCeramidesPhosphotransferases (Alcohol Group Acceptor)RabbitsSphingomyelin PhosphodiesteraseCeramidesChloride ChannelsLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Reactive Oxygen SpeciesSphingomyelin PhosphodiesteraseSphingosinesphingosine 1-phosphateCardiomyocytesMitochondriaReactive oxygen speciesSphingosine-1-phosphateVolume-sensitive chloride current

Identifiers

PMID41265704
PMCPMC13334444

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.