Evidence map›Paper›PMID 41265469›Full record

SynthesisJournal of clinical periodontology2026

Effect of Adjunctive Use of Commercial Daily Mouthwashes on Periodontal Health: An Umbrella Review.

Panagiotis A Koromantzos, Yiorgos A Bobetsis, Chrysoula Giota, Sotiria Gizani, Danae Anastasia Apatzidou, Christos Rahiotis, Sotirios Kalfas, Kyriaki Seremidi, Konstantinos Papadimitriou, Panagiotis Karakostas and 3 more

Abstract readSystematic ReviewReview
In one paragraph

Synthesis in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Panagiotis A KoromantzosDepartment of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Yiorgos A BobetsisDepartment of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Chrysoula GiotaDepartment of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Sotiria GizaniDepartment of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Danae Anastasia ApatzidouDepartment of Preventive Dentistry, Periodontology & Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Christos RahiotisDepartment of Operative Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Sotirios KalfasDepartment of Preventive Dentistry, Periodontology & Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kyriaki SeremidiDepartment of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos PapadimitriouDepartment of Preventive Dentistry, Periodontology & Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Panagiotis KarakostasDepartment of Preventive Dentistry, Periodontology & Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Sotiria DavidopoulouDepartment of Operative Dentistry, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-3436-3606
Eleftherios KaklamanosDepartment of Preventive Dentistry, Periodontology & Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-0513-5110
William PapaioannouDepartment of Preventive and Community Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0001-5146-4399

Funding

Johnson & Johnson Hellas
6 · The paper itself

Abstract

BACKGROUND AND

aimEffective oral hygiene using different mechanical means is mainly dependent on the patient. Mouthwashes containing antimicrobial agents have been developed to be used as an adjunct to mechanical supragingival plaque control. The aim of this umbrella review is to evaluate and compare the long-term efficacy of commonly used, commercially available daily mouthwashes in plaque control and gingival inflammation.

methodsThe current umbrella review was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions using the PICOS format. The search was conducted in four databases: PubMed, Scopus, Cochrane and Web of Science. Nine systematic reviews/meta-analyses (SRs/MAs) on the long-term efficacy of commercially available mouthwashes (low-concentration chlorhexidine [CHX], cetylpyridinium chloride [CPC], mouthwashes with essential oils [EOs], fluoride and oxygen-releasing mouthwashes) were included.

resultsThe results revealed that in all SRs/MAs, the prolonged daily use of mouthwashes helped in reducing plaque and gingival inflammation indices but not always with statistical significance.

conclusionsResults of the present study indicate that the long-term use of mouthwashes containing EOs seems to give the best results in both reducing plaque levels and improving gingivitis indices among all tested formulations.

trial registrationPROSPERO Registration Number CRD 42024618552.

Indexed as

Dental PlaqueGingivitisMouthwashesAnti-Infective Agents, LocalCetylpyridiniumChlorhexidineHumansOils, VolatileAnti-Infective Agents, LocalCetylpyridiniumChlorhexidineMouthwashesOils, Volatiledaily usegingival indexmouthwashplaque indexumbrella review

Identifiers

PMID41265469
PMCPMC12890455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.