Evidence map›Paper›PMID 41265381›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2025

Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model.

Zahraa I Mallah, Giovanna Petrucci, Abeer J Ayoub, Mohammad A Farhoud, Joseph G Jelwan, Sara Lucchisani, Adham K Fakih, Bassam Badran, Eva Hamade, Carlo Patrono and 2 more

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In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zahraa I MallahDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Beirut, Lebanon; Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Giovanna PetrucciDepartmental Faculty of Medicine, UniCamillus-Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
Abeer J AyoubDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Department of Biological Sciences, School of Arts and Sciences, Lebanese International University, Bekaa Campus, Bekaa, Lebanon.
Mohammad A FarhoudDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Joseph G JelwanDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
Sara LucchisaniDepartment of Translational Medicine and Surgery, Section of General Pathology, Catholic University School of Medicine, Rome, Italy.
Adham K FakihDepartment of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
Bassam BadranLaboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Beirut, Lebanon.
Eva HamadeLaboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Beirut, Lebanon.
Carlo PatronoCenter of Excellence on Ageing, CAST, "G. d'Annunzio" University School of Medicine, Chieti, Italy.
Bianca RoccaDepartment of Medicine and Surgery, LUM University, Casamassima, Bari, Italy; Department of Radiological and Hematological Sciences, Catholic University, Roma, Italy. Electronic address: rocca@lum.it.
Aida HabibDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar; Clinical Translational Science Group, Research and Graduate Studies, QU Health, Qatar University, Doha, Qatar. Electronic address: aida.habib@qu.edu.qa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-dose aspirin irreversibly acetylates cyclooxygenase (COX)-1 in anucleate platelets and progenitor megakaryocytes, permanently suppressing thromboxane (TX)A

Indexed as

AspirinCyclooxygenase 1Cyclooxygenase InhibitorsMegakaryocytesThromboxane B2ThromboxanesCell LineCyclooxygenase 2HumansAspirinCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase InhibitorsPTGS1 protein, humanThromboxane B2ThromboxanesAspirinCyclooxygenase-1MegakaryocytesPlateletsThromboxane

Identifiers

PMID41265381
PMCPMC12799507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.