Evidence map›Paper›PMID 41264875›Full record

ArticleThe Journal of organic chemistry2025

Impact of Strand Edge N-Amination on the Stability of a Parallel β-Hairpin Fold.

Syrah K Starnes, W Seth Horne, Juan R Del Valle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Syrah K StarnesDepartment of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
W Seth HorneDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0003-2927-1739
Juan R Del ValleDepartment of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-7964-8402

Funding

Chemical approaches to selectively target beta-rich amyloidsR01AG074570 · NIA · UNIVERSITY OF NOTRE DAME · PI DEL VALLE, JUAN R · 2021 to 2025
$2.5M
Chemistry-Biochemistry-Biology Interface (CBBI) Program at Notre DameT32GM145773 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Christian Corey Melander · 2022 to 2026
$1.5M
Exploring the Impact of Altered Backbone Composition on Protein Folding and FunctionR35GM149220 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILLIAM SETH HORNE · 2023 to 2026
$1.4M
NIA NIH HHS R01 AG074570NIGMS NIH HHS R35 GM149220NIGMS NIH HHS T32 GM145773
6 · The paper itself

Abstract

Peptide backbone N-amination has emerged as a useful strategy to stabilize antiparallel β-sheet structure. Here, we used circular dichroism and NMR to evaluate the impact of amide-to-hydrazide substitution on the folded population of a parallel β-hairpin model. Outer-edge N-amination was well tolerated and resulted in enhanced stability relative to N-methylation. High-resolution NMR structures confirmed that the α-hydrazino acid residues adopt canonical parallel β-strand torsions that are compatible with the formation of intraresidue C6 hydrogen bonds involving the hydrazide NH

Indexed as

PeptidesAminationCircular DichroismHydrogen BondingMagnetic Resonance SpectroscopyModels, MolecularProtein Conformation, beta-StrandProtein FoldingProtein Structure, SecondaryPeptides

Identifiers

PMID41264875
PMCPMC12758975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.