ArticleJMIR formative research2025
Compliance and Satisfaction With a Protocol for Identifying Novel Targets to Support Postpartum Opioid Use Disorder Recovery: Prospective Cohort Study.
Article in JMIR formative research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring hormonal influences on nicotine craving and use across the perinatal period: A prospective longitudinal study.Drug and alcohol dependence reports · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Background: Although treatment for opioid use disorder (OUD) often yields high adherence during pregnancy, the risk of returning to opioid misuse during postpartum is high. There are currently no relapse prevention programs tailored to this unique time period. Using a prospective cohort study, we seek to preliminarily identify hormones or infant caregiving approaches as novel predictors of postpartum opioid misuse. Objective: As a first step in dissemination of results, this report contains a detailed account of the protocol, as well as recruitment, retention, compliance, and participant satisfaction. Methods: Participants were individuals with OUD (OUD+) and those without (OUD-) who were followed from late pregnancy (≥36 gestational wk) to postpartum month 5. From childbirth to postpartum week 12, participants completed daily surveys (capturing use, craving, interactions with infant) and weekly face-to-face visits (including collection of biological samples for hormone assays). Follow-up visits using the same procedures occurred at postpartum month 4 and 5. Results: Most participants (50 OUD+, 20 OUD-) notified the study staff of childbirth (n=63, 93%), completed at least 1 postpartum clinic visit (n=62, 87%), and completed follow-up (n=51, 73%). Compliance with procedures ranged from 81% for weekly surveys to 63% for weekly dried blood spots, generally with lower compliance among OUD+ and at later time points. Among a subgroup of participants (n=31), regardless of group and time point, reported high study satisfaction (eg, on a scale where 0 is "not at all" and 3 is "extremely," on average, participants reported 2.9±0.4 for their willingness to complete this study again at week 12 postpartum). Conclusions: This prospective cohort study was well tolerated despite the challenging postpartum period. Data collected will provide ample opportunities to identify novel risk or protective factors to inform the development of new relapse prevention intervention programs specific to the needs of those with OUD during early postpartum.
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Registered trials
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