Evidence map›Paper›PMID 41264802›Full record

ArticleACS biomaterials science & engineering2025

TYRAY-Functionalized Alginate Bioinks for 3D Bioprinting Support Stem Cell Culture and Endothelial Network Formation.

Vaclav Chochola, Karolina Spustova, Josef Lavicky, Anna Golunova, Jakub Pospisil, Jana Dvořáková, Ilya Kotelnikov, Mario Kandra, Libor Streit, Ariel Szklanny and 4 more

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vaclav ChocholaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.ORCID 0000-0003-3674-5701
Karolina SpustovaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.
Josef LavickyDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.
Anna GolunovaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, Prague 16200, Czech Republic.ORCID 0000-0001-8364-3770
Jakub PospisilDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.ORCID 0000-0002-8679-677X
Jana DvořákováInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, Prague 16200, Czech Republic.ORCID 0000-0002-5594-7360
Ilya KotelnikovInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, Prague 16200, Czech Republic.
Mario KandraDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.
Libor StreitDepartment of Burns and Plastic Surgery, University Hospital Brno & Faculty of Medicine, Masaryk University, Jihlavska 20, Brno 62500, Czech Republic.
Ariel SzklannyDepartment of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
Shulamit LevenbergDepartment of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.ORCID 0000-0001-5471-7339
Vladimir ProksInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, Prague 16200, Czech Republic.ORCID 0000-0001-7368-7120
Ales HamplDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.
Josef JarosDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 62500, Czech Republic.ORCID 0000-0001-7559-2344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3D bioprinting is transforming tissue engineering by enabling spatial arrangement of cells and cell aggregates within supportive hydrogels. Among available materials, alginate remains widely used for its biocompatibility, printability, and cost-effectiveness. However, its bioinert nature and lack of adhesive moieties restrict its capacity to support essential processes like cell adhesion, migration, and proliferation. In this study, we propose a comprehensive approach to enhance alginate hydrogels focusing on stem, stromal, and endothelial cell types to support extended growth and vascular network formation. Key innovations include the incorporation of the TYRAY peptide in 3D alginate hydrogels─its first application in this context─to promote cell adhesion and migration, accompanied by Ca(OH)

Indexed as

AlginatesBioprintingEndothelial CellsPrinting, Three-DimensionalStem CellsCell AdhesionCell ProliferationCells, CulturedGlucuronic AcidHexuronic AcidsHumansHydrogelsInkTissue EngineeringTissue ScaffoldsAlginatesGlucuronic AcidHexuronic AcidsHydrogels3D bioprintingalginatebioinkendothelial networkspeptide functionalizationpluripotent stem cellsspheroid fusionTYRAYvascularization

Identifiers

PMID41264802
PMCPMC12690512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.