ArticleScience (New York, N.Y.)2025
Intracellular competition shapes plasmid population dynamics.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Invasive plasmids as ecosystem engineers-from mechanism to application.Essays in biochemistry · 2026Review
- Revisiting the molecular workhorse: plasmids in evolutionary conflict.Nature reviews. Genetics · 2026Article
- Rational engineering of combinatorial bacterial therapies for cancer.Genome biology · 2026Review
- Plasmid mutation rates scale with copy number.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tuning evolvability via plasmid copy number and regulatory architecture.Nature communications · 2025Article
- Intracellular competition shapes plasmid population dynamics.Science (New York, N.Y.) · 2025Article
- Plasmid streamlining drives the extinction of antibiotic resistance plasmids under selection for horizontal transmission.PLoS biology · 2025Article
- The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness.Nature communications · 2025Article
- RNA-guided nucleases enable a gene drive of insertion sequences in plasmids.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating genetic elements that face selective pressures from their hosts but also compete within the host cell for replication resources. Although theory indicates that within-cell selection matters for plasmid evolution, experimental measurement of these dynamics has remained elusive. We measured within-cell fitness of competing
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.